2-({Cyclopropyl-[2,5-difluoro-3-(4-methyl-piperazin-1-yl)-4-nitro-phenyl]-amino}-methylene)-malonic acid diethyl ester

Base Information

Chemical Name:2-({Cyclopropyl-[2,5-difluoro-3-(4-methyl-piperazin-1-yl)-4-nitro-phenyl]-amino}-methylene)-malonic acid diethyl ester
CAS No.:161040-89-7
Molecular Formula:C₂₂H₂₈F₂N₄O₆
Molecular Weight:482.484
Hs Code.:

Synonyms:2-({Cyclopropyl-[2,5-difluoro-3-(4-methyl-piperazin-1-yl)-4-nitro-phenyl]-amino}-methylene)-malonic acid diethyl ester

Suppliers and Price of 2-({Cyclopropyl-[2,5-difluoro-3-(4-methyl-piperazin-1-yl)-4-nitro-phenyl]-amino}-methylene)-malonic acid diethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-({Cyclopropyl-[2,5-difluoro-3-(4-methyl-piperazin-1-yl)-4-nitro-phenyl]-amino}-methylene)-malonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-({Cyclopropyl-[2,5-difluoro-3-(4-methyl-piperazin-1-yl)-4-nitro-phenyl]-amino}-methylene)-malonic acid diethyl ester

There total 4 articles about 2-({Cyclopropyl-[2,5-difluoro-3-(4-methyl-piperazin-1-yl)-4-nitro-phenyl]-amino}-methylene)-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 161040-86-4
Cyclopropyl-[2,5-difluoro-3-(4-methyl-piperazin-1-yl)-4-nitro-phenyl]-amine

: 161040-89-7
2-({Cyclopropyl-[2,5-difluoro-3-(4-methyl-piperazin-1-yl)-4-nitro-phenyl]-amino}-methylene)-malonic acid diethyl ester

Guidance literature:: at 140 ℃; for 36h;
DOI:10.1021/jm00006a017

Reference yield:

: 109-01-3
1-methyl-piperazine

: 161040-89-7
2-({Cyclopropyl-[2,5-difluoro-3-(4-methyl-piperazin-1-yl)-4-nitro-phenyl]-amino}-methylene)-malonic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 33 percent / toluene / 5 h / Ambient temperature

2: 54 percent / HMPA / 45 °C

3: 39 percent / 36 h / 140 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; In toluene;
DOI:10.1021/jm00006a017

Reference yield:

: 314-41-0
1,2,3,5-tetrafluoro-4-nitrobenzene

: 161040-89-7
2-({Cyclopropyl-[2,5-difluoro-3-(4-methyl-piperazin-1-yl)-4-nitro-phenyl]-amino}-methylene)-malonic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 33 percent / toluene / 5 h / Ambient temperature

2: 54 percent / HMPA / 45 °C

3: 39 percent / 36 h / 140 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; In toluene;
DOI:10.1021/jm00006a017