2-(2-(2-phenylbenzyl)-1-oxoisoindolin-6-yloxy)-N-(tetrahydro-2H-pyran-2-yloxy)acetamide

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Chemical Name:2-(2-(2-phenylbenzyl)-1-oxoisoindolin-6-yloxy)-N-(tetrahydro-2H-pyran-2-yloxy)acetamide
CAS No.:914647-68-0
Molecular Formula:C₂₈H₂₈N₂O₅
Molecular Weight:472.541
Hs Code.:

Synonyms:2-(2-(2-phenylbenzyl)-1-oxoisoindolin-6-yloxy)-N-(tetrahydro-2H-pyran-2-yloxy)acetamide

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Chemical Property of 2-(2-(2-phenylbenzyl)-1-oxoisoindolin-6-yloxy)-N-(tetrahydro-2H-pyran-2-yloxy)acetamide

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Technology Process of 2-(2-(2-phenylbenzyl)-1-oxoisoindolin-6-yloxy)-N-(tetrahydro-2H-pyran-2-yloxy)acetamide

There total 6 articles about 2-(2-(2-phenylbenzyl)-1-oxoisoindolin-6-yloxy)-N-(tetrahydro-2H-pyran-2-yloxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 914647-63-5
2-(2-(2-phenylbenzyl)-1-oxoisoindolin-6-yloxy)acetic acid

: 6723-30-4
O-2-tetrahydro-2H-pyranhydroxylamine

: 914647-68-0
2-(2-(2-phenylbenzyl)-1-oxoisoindolin-6-yloxy)-N-(tetrahydro-2H-pyran-2-yloxy)acetamide

Guidance literature:: 2-(2-(2-phenylbenzyl)-1-oxoisoindolin-6-yloxy)acetic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃;

O-2-tetrahydro-2H-pyranhydroxylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmc.2006.07.008

Reference yield:

: 914647-54-4
methyl 5-((tert-butoxycarbonyl)methoxy)-2-methylbenzoate

: 914647-68-0
2-(2-(2-phenylbenzyl)-1-oxoisoindolin-6-yloxy)-N-(tetrahydro-2H-pyran-2-yloxy)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 57 percent / N-bromosuccinimide; benzoyl peroxide / CCl₄ / Heating

2.1: 80 percent / triethylamine / methanol / Heating

3.1: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 20 °C

4.1: ethyl chloroformate; triethylamine / tetrahydrofuran / 0 °C

4.2: 45 percent / tetrahydrofuran / 20 °C

With N-Bromosuccinimide; chloroformic acid ethyl ester; triethylamine; trifluoroacetic acid; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane;
DOI:10.1016/j.bmc.2006.07.008

Reference yield:

: 914647-55-5
methyl 5-((tert-butoxycarbonyl)methoxy)-2-(bromomethyl)benzoate

: 914647-68-0
2-(2-(2-phenylbenzyl)-1-oxoisoindolin-6-yloxy)-N-(tetrahydro-2H-pyran-2-yloxy)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 80 percent / triethylamine / methanol / Heating

2.1: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 20 °C

3.1: ethyl chloroformate; triethylamine / tetrahydrofuran / 0 °C

3.2: 45 percent / tetrahydrofuran / 20 °C

With chloroformic acid ethyl ester; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmc.2006.07.008