1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid

Base Information

• Chemical Name: 1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid
• CAS No.: 861151-23-7
• Molecular Formula: C₁₆H₁₃ClN₂O₂
• Molecular Weight: 300.744
• Mol file: 861151-23-7.mol

Synonyms:1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid

Chemical Property of 1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid

There total 1 articles about 1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester (861151-22-6) → 1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid (861151-23-7)

Guidance literature:

With potassium hydroxide; In methanol; at 65 - 68 ℃; for 2h;

DOI:10.1021/jm061490u

Reference yield: 82.0%

1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid (861151-23-7) + piperidine-1-sulfonamide (4108-90-1) → N-[(piperidin-1-yl)sulfonyl]-1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-(1H)-pyrazole-3-carboxamide

Guidance literature:

1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid; With thionyl chloride; In toluene; at 80 ℃; for 1h;

piperidine-1-sulfonamide; With sodium hydride; In acetonitrile; at 20 ℃; for 16h;

Reference yield: 79.0%

1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid (861151-23-7) + 4-Chlorobenzenesulfonamide (98-64-6) → 1-(4-chlorophenyl)-N-((4-chlorophenyl)sulfonyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxamide

Guidance literature:

1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid; With thionyl chloride; In toluene; at 80 ℃; for 1h;

4-Chlorobenzenesulfonamide; With sodium hydroxide; In acetonitrile; at 20 ℃; for 16h;

upstream raw materials:

1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester

Downstream raw materials:

1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-(1H)-pyrazole-3-carboxylic acid chloride

N-[(4,4-difluoropiperidin-1-yl)sulfonyl]-1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-(1H)-pyrazole-3-carboxamide

(5R)-(+)-N-[(4,4-difluoropiperidin-1-yl)sulfonyl]-N'-methyl-1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-(1H)-pyrazole-3-carboxamidine

(5S)-(-)-N-[(4,4-difluoropiperidin-1-yl)sulfonyl]-N'-methyl-1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-(1H)-pyrazole-3-carboxamidine