1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester
• CAS No.: 861151-22-6
• Molecular Formula: C₁₈H₁₇ClN₂O₂
• Molecular Weight: 328.798
• Mol file: 861151-22-6.mol

Synonyms:1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester

Chemical Property of 1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester

There total 2 articles about 1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + ethyl 2-chloro[(4-chlorophenyl)hydrazono]acetate (27143-09-5,132839-05-5) → 1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester (861151-22-6)

Guidance literature:

With triethylamine; In benzene; for 1h; Heating / reflux;

Reference yield:

4-chlorophenylhydrazine hydrochloride (1073-70-7) + (E)-ethyl-2-oxo-4-phenylbut-3-enoate (17451-20-6,55674-14-1,55629-96-4) → 1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester (861151-22-6)

Guidance literature:

4-chlorophenylhydrazine hydrochloride; (E)-ethyl-2-oxo-4-phenylbut-3-enoate; In ethanol; at 28 - 31 ℃; for 2h;

With acetic acid; In ethanol; at 108 - 110 ℃; for 18h; Further stages.;

DOI:10.1021/jm061490u

Reference yield: 85.0%

1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester (861151-22-6) → 1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid (861151-23-7)

Guidance literature:

With potassium hydroxide; In methanol; at 65 - 68 ℃; for 2h;

DOI:10.1021/jm061490u

upstream raw materials:

4-chlorophenylhydrazine hydrochloride

(E)-ethyl-2-oxo-4-phenylbut-3-enoate

styrene

ethyl 2-chloro[(4-chlorophenyl)hydrazono]acetate

Downstream raw materials:

1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid