N-(3-(5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrazol-1-yl)phenyl)acetamide

Base Information

Chemical Name:N-(3-(5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrazol-1-yl)phenyl)acetamide
CAS No.:1430724-58-5
Molecular Formula:C₂₆H₂₆N₈O
Molecular Weight:466.545
Hs Code.:

Synonyms:N-(3-(5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrazol-1-yl)phenyl)acetamide

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Chemical Property of N-(3-(5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrazol-1-yl)phenyl)acetamide

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Technology Process of N-(3-(5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrazol-1-yl)phenyl)acetamide

There total 15 articles about N-(3-(5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrazol-1-yl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1430728-12-3
tert-butyl 4-(4-(1-(3-acetamido-5-(1H-pyrazol-1-yl)phenyl)-1H-benzo[d]imidazol-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

: 1430724-58-5
N-(3-(5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrazol-1-yl)phenyl)acetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h;

Reference yield:

: 877399-50-3
4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester

: 1430724-58-5
N-(3-(5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrazol-1-yl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 12 h / 110 °C / Inert atmosphere

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 90 °C

3: trifluoroacetic acid / dichloromethane / 6 h / 0 - 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; sodium carbonate; trifluoroacetic acid; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 18242-39-2
3,5-dinitrobromobenzene

: 1430724-58-5
N-(3-(5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrazol-1-yl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 9 steps

1: acetic acid; iron / acetic acid / 0.5 h / 90 °C

2: 0.5 h / 0 - 20 °C

3: caesium carbonate; copper(I) oxide / N,N-dimethyl-formamide / 16 h / 120 °C

4: water; calcium chloride; iron / ethanol / 4 h / 100 °C

5: potassium fluoride / N,N-dimethyl-formamide / 4 h / 150 °C

6: water; calcium chloride; iron / ethanol / 4 h / 100 °C

7: 0.5 h / 100 °C

8: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 90 °C

9: trifluoroacetic acid / dichloromethane / 6 h / 0 - 20 °C

With copper(I) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; water; iron; sodium carbonate; caesium carbonate; acetic acid; trifluoroacetic acid; calcium chloride; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;