methanesulfonic acid (R)-4-{[6-(3-chloro-4-fluorobenzyl)-3-methanesulfonyloxy-4-methoxy-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carbonyl]-methyl-amino}-2,2-dimethyl-3-(tetrahydropyran-2-yloxy)-butyl ester

Base Information

Chemical Name:methanesulfonic acid (R)-4-{[6-(3-chloro-4-fluorobenzyl)-3-methanesulfonyloxy-4-methoxy-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carbonyl]-methyl-amino}-2,2-dimethyl-3-(tetrahydropyran-2-yloxy)-butyl ester
CAS No.:1080623-44-4
Molecular Formula:C₃₁H₄₁ClFN₃O₁₁S₂
Molecular Weight:750.263
Hs Code.:

methanesulfonic acid (R)-4-{[6-(3-chloro-4-fluorobenzyl)-3-methanesulfonyloxy-4-methoxy-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carbonyl]-methyl-amino}-2,2-dimethyl-3-(tetrahydropyran-2-yloxy)-butyl ester

Synonyms:methanesulfonic acid (R)-4-{[6-(3-chloro-4-fluorobenzyl)-3-methanesulfonyloxy-4-methoxy-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carbonyl]-methyl-amino}-2,2-dimethyl-3-(tetrahydropyran-2-yloxy)-butyl ester

Suppliers and Price of methanesulfonic acid (R)-4-{[6-(3-chloro-4-fluorobenzyl)-3-methanesulfonyloxy-4-methoxy-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carbonyl]-methyl-amino}-2,2-dimethyl-3-(tetrahydropyran-2-yloxy)-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methanesulfonic acid (R)-4-{[6-(3-chloro-4-fluorobenzyl)-3-methanesulfonyloxy-4-methoxy-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carbonyl]-methyl-amino}-2,2-dimethyl-3-(tetrahydropyran-2-yloxy)-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methanesulfonic acid (R)-4-{[6-(3-chloro-4-fluorobenzyl)-3-methanesulfonyloxy-4-methoxy-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carbonyl]-methyl-amino}-2,2-dimethyl-3-(tetrahydropyran-2-yloxy)-butyl ester

There total 23 articles about methanesulfonic acid (R)-4-{[6-(3-chloro-4-fluorobenzyl)-3-methanesulfonyloxy-4-methoxy-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carbonyl]-methyl-amino}-2,2-dimethyl-3-(tetrahydropyran-2-yloxy)-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1080623-40-0
methanesulfonic acid (R)-4-{[6-(3-chloro-4-fluorobenzyl)-3,4-bis(methanesulfonyloxy)-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carbonyl]-methyl-amino}-2,2-dimethyl-3-(tetrahydropyran-2-yloxy)-butyl ester

: 74-88-4
methyl iodide

: 1080623-44-4
methanesulfonic acid (R)-4-{[6-(3-chloro-4-fluorobenzyl)-3-methanesulfonyloxy-4-methoxy-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carbonyl]-methyl-amino}-2,2-dimethyl-3-(tetrahydropyran-2-yloxy)-butyl ester

Guidance literature:: methanesulfonic acid (R)-4-{[6-(3-chloro-4-fluorobenzyl)-3,4-bis(methanesulfonyloxy)-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carbonyl]-methyl-amino}-2,2-dimethyl-3-(tetrahydropyran-2-yloxy)-butyl ester; With caesium carbonate; In N,N-dimethyl acetamide; at 80 ℃; for 2h; Large scale;

methyl iodide; In N,N-dimethyl acetamide; at 20 ℃; for 15h; Large scale;
DOI:10.1021/acs.joc.6b01229

Reference yield:

: 1019339-37-7
6-(3-chloro-4-fluorobenzyl)-N-[(2R)-4-hydroxy-3,3-dimethyl-2-(tetrahydro-2H-pyran-2-yloxy)butyl]-4-methoxy-N-methyl-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxamide

: 7143-01-3
Methanesulfonic anhydride

: C₃₀H₃₉ClFN₃O₉S

: 1080623-44-4
methanesulfonic acid (R)-4-{[6-(3-chloro-4-fluorobenzyl)-3-methanesulfonyloxy-4-methoxy-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carbonyl]-methyl-amino}-2,2-dimethyl-3-(tetrahydropyran-2-yloxy)-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 147331-80-4
(3R)-dihydro-4,4-dimethyl-3-(2-tetrahydropyranyloxy)-2(3H)-furanone

: 1080623-44-4
methanesulfonic acid (R)-4-{[6-(3-chloro-4-fluorobenzyl)-3-methanesulfonyloxy-4-methoxy-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carbonyl]-methyl-amino}-2,2-dimethyl-3-(tetrahydropyran-2-yloxy)-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 18 h / 20 °C

2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 4.75 h / -5 - 90 °C / Large scale

3.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 20 °C / Large scale

4.1: triethylamine / ethyl acetate / 1 h / 5 - 20 °C / Large scale

5.1: caesium carbonate / N,N-dimethyl acetamide / 2 h / 80 °C / Large scale

5.2: 15 h / 20 °C / Large scale

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In ethanol; N,N-dimethyl acetamide; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acs.joc.6b01229