2-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl-3-hydroxypropylamino)-2-methylpropane

Base Information

Chemical Name:2-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl-3-hydroxypropylamino)-2-methylpropane
CAS No.:1258834-19-3
Molecular Formula:C₂₀H₃₂N₂O₅
Molecular Weight:380.484
Hs Code.:

Synonyms:2-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl-3-hydroxypropylamino)-2-methylpropane

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Chemical Property of 2-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl-3-hydroxypropylamino)-2-methylpropane

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Technology Process of 2-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl-3-hydroxypropylamino)-2-methylpropane

There total 3 articles about 2-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl-3-hydroxypropylamino)-2-methylpropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 114856-91-6
benzyl (2-methyl-1-oxopropan-2-yl)carbamate

: 156-87-6
propan-1-ol-3-amine

: 1258834-19-3
2-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl-3-hydroxypropylamino)-2-methylpropane

Guidance literature:: benzyl (2-methyl-1-oxopropan-2-yl)carbamate; propan-1-ol-3-amine; With sodium cyanoborohydride; acetic acid; In methanol; at 0 - 20 ℃; for 1h;

di-tert-butyl dicarbonate; With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 2h;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1258834-19-3
2-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl-3-hydroxypropylamino)-2-methylpropane

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / dichloromethane; water / 16 h / 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.17 h / -78 °C

2.2: 1.67 h / -78 - -10 °C

3.1: sodium cyanoborohydride; acetic acid / methanol / 1 h / 0 - 20 °C

3.2: 2 h / 20 °C

With oxalyl dichloride; sodium cyanoborohydride; sodium hydrogencarbonate; acetic acid; dimethyl sulfoxide; In methanol; dichloromethane; water;

Reference yield:

: 62471-40-3
2-benzyloxycarbonylamino-2-methylpropanol

: 1258834-19-3
2-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl-3-hydroxypropylamino)-2-methylpropane

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.17 h / -78 °C

1.2: 1.67 h / -78 - -10 °C

2.1: sodium cyanoborohydride; acetic acid / methanol / 1 h / 0 - 20 °C

2.2: 2 h / 20 °C

With oxalyl dichloride; sodium cyanoborohydride; acetic acid; dimethyl sulfoxide; In methanol; dichloromethane;