1-(4-(benzothiazol-2-ylamino)piperidin-1-yl)-3-(3,4-difluorophenoxy)propan-2-ol

Base Information

• Chemical Name: 1-(4-(benzothiazol-2-ylamino)piperidin-1-yl)-3-(3,4-difluorophenoxy)propan-2-ol
• CAS No.: 1425504-46-6
• Molecular Formula: C₂₁H₂₃F₂N₃O₂S
• Molecular Weight: 419.495

Synonyms:1-(4-(benzothiazol-2-ylamino)piperidin-1-yl)-3-(3,4-difluorophenoxy)propan-2-ol

Chemical Property of 1-(4-(benzothiazol-2-ylamino)piperidin-1-yl)-3-(3,4-difluorophenoxy)propan-2-ol

Chemical Property:

Purity/Quality:

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Technology Process of 1-(4-(benzothiazol-2-ylamino)piperidin-1-yl)-3-(3,4-difluorophenoxy)propan-2-ol

There total 3 articles about 1-(4-(benzothiazol-2-ylamino)piperidin-1-yl)-3-(3,4-difluorophenoxy)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-chlorobenzo[d][1,3]thiazole (615-20-3) + 1-(4-aminopiperidin-1-yl)-3-(3,4-difluorophenoxy)propan-2-ol (188174-28-9) → 1-(4-(benzothiazol-2-ylamino)piperidin-1-yl)-3-(3,4-difluorophenoxy)propan-2-ol (1425504-46-6)

Guidance literature:

In water; at 110 ℃; for 10h; Solvent; Time; Temperature;

DOI:10.1021/ol302601b

Reference yield:

3,4-difluorophenol (2713-33-9) → 1-(4-(benzothiazol-2-ylamino)piperidin-1-yl)-3-(3,4-difluorophenoxy)propan-2-ol (1425504-46-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 14 h / Reflux

2: water / 2 h / 10 °C

3: water / 10 h / 110 °C

With potassium carbonate; In water; acetonitrile;

DOI:10.1021/ol302601b

Reference yield:

1-(3,4-difluorophenoxy)-2,3-epoxypropane (170876-51-4) → 1-(4-(benzothiazol-2-ylamino)piperidin-1-yl)-3-(3,4-difluorophenoxy)propan-2-ol (1425504-46-6)

Guidance literature:

Multi-step reaction with 2 steps

1: water / 2 h / 10 °C

2: water / 10 h / 110 °C

In water;

DOI:10.1021/ol302601b

upstream raw materials:

3,4-difluorophenol

2-chlorobenzo[d][1,3]thiazole

1-(4-aminopiperidin-1-yl)-3-(3,4-difluorophenoxy)propan-2-ol

1-(3,4-difluorophenoxy)-2,3-epoxypropane

Downstream raw materials:

lubeluzole

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