170876-51-4

Usage

Uses

Used in Chemical Synthesis:
1-(3,4-difluorophenoxy)-2,3-epoxypropane is used as a building block in the chemical industry for the production of other chemicals. Its reactivity allows it to be a versatile component in the synthesis of a range of compounds.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 1-(3,4-difluorophenoxy)-2,3-epoxypropane is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure contributes to the development of new drugs.
Used in Agrochemical Production:
1-(3,4-difluorophenoxy)-2,3-epoxypropane is also utilized in the agrochemical sector, where it serves as a starting material for the creation of different agrochemicals that are used in the agricultural industry.
Used as a Solvent:
Due to its liquid state and chemical properties, 1-(3,4-difluorophenoxy)-2,3-epoxypropane is used as a solvent in various industrial processes. Its solvent properties make it suitable for dissolving and processing other substances in a controlled environment.
Safety and Handling:
Given its toxic nature and potential to cause irritation to the skin, eyes, and respiratory system, 1-(3,4-difluorophenoxy)-2,3-epoxypropane must be handled with care. It is classified as a potential carcinogen, and proper safety measures, including the use of personal protective equipment and adherence to disposal protocols, are essential to minimize health and environmental risks.

Upstream product

• 2713-33-9 3,4-difluorophenol 
• 106-89-8 epichlorohydrin 

Downstream Products

• 1449846-89-2 (-)-(R)-3-(3,4-difluorophenoxy)propane-1,2-diol 
• 144665-07-6 (-)-Lubeluzole 
• 1449846-90-5 (+)-(S)-3-(3,4-difluorophenoxy)-2-hydroxypropyl 4-methylbenzenesulfonate 
• 144665-07-6 lubeluzole 
• 188174-28-9 1-(4-aminopiperidin-1-yl)-3-(3,4-difluorophenoxy)propan-2-ol 
• 1425504-52-4 1-(3,4-difluorophenoxy)-3-{4-[3-(3,4-difluorophenoxy)-2-hydroxypropylamino]piperidin-1-yl}propan-2-ol 
• 144665-07-6 lubeluzole 
• 1425504-46-6 1-(4-(benzothiazol-2-ylamino)piperidin-1-yl)-3-(3,4-difluorophenoxy)propan-2-ol 
• 1425504-53-5 C₁₆H₂₄F₂N₂O₂ 

Relevant academic research and scientific papers

Enantioselective transesterification of (RS)-1-chloro-3-(3,4-difluorophenoxy)-2-propanol using Pseudomonas aeruginosa lipases

Lipases from the bacterial strain, Pseudomonas aeruginosa, isolated from the soil by enrichment techniques, are assessed for the enantioselective transesterification of (RS)-1-chloro-3-(3,4-difluorophenoxy)-2-propanol (rac-CDPP) to (R)-1-chloro-3-(3,4-dif

Solvent-Directed Epoxide Opening with Primary Amines for the Synthesis of β-Amino Alcohols

An efficient synthesis of β-amino alcohols from a variety of epoxides and primary unbranched amines in the absence of any catalyst in high yields and regioselectivities is reported. A variety of polar mixed solvent systems allow for the selective formation of secondary amino alcohols over tertiary amino alcohols. The reaction scope extends to a wide variety of aromatic and aliphatic substituted epoxides and primary amines bearing complex functionality.

The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca2+/calmodulin-dependent kinase II

An affinity capillary electrophoresis (ACE) method to estimate apparent dissociation constants between bovine brain calmodulin (CaM) and non-peptidic ligands was developed. The method was validated reproducing the dissociation constants of a number of wel

Protecting group-free concise synthesis of (RS)/(S)-lubeluzole

Three new, concise, and protecting group-free synthetic routes for (RS)- and (S)-lubeluzole are reported in higher (46-62%) overall yields compared to the reported procedures (6-35%). The key steps involve C-N bond formation via epoxide aminolysis and nucleophilic substitution of 2-chlorobenzothiazole with suitably designed precursor amines and are performed in aqueous medium. Water offers an advantage in promoting the reactions compared to organic solvents and its role is envisaged as hydrogen-bond mediated electrophile-nucleophile dual activation.

SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF

The present invention relates to a series of substituted dihydro and tetrahydro oxazolopyrimidinones, specifically, to a series of 2-substituted-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-ones and 2-substituted-2,3,5,6-tetra-hydro-oxazolo[3,2-a]pyrimidin-7-ones of formula (I): Wherein p, n, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of this invention are modulators of metabotropic glutamate receptors (mGluR), particularly, mGluR2 receptor. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic neurodegenerative conditions, psychoses, convulsions, anxiety, depression, migraine, pain, sleep disorders and emesis.

Studies on new phosphodiesterase inhibitors. I. Synthesis of 1-(2,3-epoxypropoxy)-2(4)-fluorobenzenes and 1-(2-hydroxy-3-morpholinopropoxy and piperazino)fluorobenzene derivatives

A series of 1-(2,3-epoxypropoxy)-2(4)-fluorobenzenes and their corresponding 1-(2-hydroxy-3-morpholino propoxy and piperazino)fluorobenzene derivatives (8a-f) were synthesised via a short synthetic route in good chemical yields and were evaluated for inot