(2S,3S)-2-{(S)-2-[3-(2-Cyano-ethyl)-3-(2-phenylamino-ethyl)-ureido]-3-phenyl-propionylamino}-3-methyl-pentanoic acid ((S)-3-methyl-1-methylcarbamoyl-butyl)-amide

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Chemical Name:(2S,3S)-2-{(S)-2-[3-(2-Cyano-ethyl)-3-(2-phenylamino-ethyl)-ureido]-3-phenyl-propionylamino}-3-methyl-pentanoic acid ((S)-3-methyl-1-methylcarbamoyl-butyl)-amide
CAS No.:249761-54-4
Molecular Formula:C₃₄H₄₉N₇O₄
Molecular Weight:619.808
Hs Code.:

(2S,3S)-2-{(S)-2-[3-(2-Cyano-ethyl)-3-(2-phenylamino-ethyl)-ureido]-3-phenyl-propionylamino}-3-methyl-pentanoic acid ((S)-3-methyl-1-methylcarbamoyl-butyl)-amide

Synonyms:(2S,3S)-2-{(S)-2-[3-(2-Cyano-ethyl)-3-(2-phenylamino-ethyl)-ureido]-3-phenyl-propionylamino}-3-methyl-pentanoic acid ((S)-3-methyl-1-methylcarbamoyl-butyl)-amide

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Chemical Property of (2S,3S)-2-{(S)-2-[3-(2-Cyano-ethyl)-3-(2-phenylamino-ethyl)-ureido]-3-phenyl-propionylamino}-3-methyl-pentanoic acid ((S)-3-methyl-1-methylcarbamoyl-butyl)-amide

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Technology Process of (2S,3S)-2-{(S)-2-[3-(2-Cyano-ethyl)-3-(2-phenylamino-ethyl)-ureido]-3-phenyl-propionylamino}-3-methyl-pentanoic acid ((S)-3-methyl-1-methylcarbamoyl-butyl)-amide

There total 3 articles about (2S,3S)-2-{(S)-2-[3-(2-Cyano-ethyl)-3-(2-phenylamino-ethyl)-ureido]-3-phenyl-propionylamino}-3-methyl-pentanoic acid ((S)-3-methyl-1-methylcarbamoyl-butyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 74-89-5
methylamine

: 249761-55-5
(S)-2-((2S,3S)-2-{(S)-2-[3-(2-Cyano-ethyl)-3-(2-phenylamino-ethyl)-ureido]-3-phenyl-propionylamino}-3-methyl-pentanoylamino)-4-methyl-pentanoic acid methyl ester

: 249761-54-4
(2S,3S)-2-{(S)-2-[3-(2-Cyano-ethyl)-3-(2-phenylamino-ethyl)-ureido]-3-phenyl-propionylamino}-3-methyl-pentanoic acid ((S)-3-methyl-1-methylcarbamoyl-butyl)-amide

Guidance literature:: In methanol;
DOI:10.1021/ja992109g

Reference yield:

: 161943-97-1
3-(2-Phenylamino-ethylamino)-propionitrile

: 249761-54-4
(2S,3S)-2-{(S)-2-[3-(2-Cyano-ethyl)-3-(2-phenylamino-ethyl)-ureido]-3-phenyl-propionylamino}-3-methyl-pentanoic acid ((S)-3-methyl-1-methylcarbamoyl-butyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / CH₂Cl₂

2: 90 percent / methanol

In methanol; dichloromethane; 1: Addition / 2: Substitution;
DOI:10.1021/ja992109g

Reference yield:

: 177763-26-7
phenylalanylisoleucylleucine methyl ester isocyanate

: 249761-54-4
(2S,3S)-2-{(S)-2-[3-(2-Cyano-ethyl)-3-(2-phenylamino-ethyl)-ureido]-3-phenyl-propionylamino}-3-methyl-pentanoic acid ((S)-3-methyl-1-methylcarbamoyl-butyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / CH₂Cl₂

2: 90 percent / methanol

In methanol; dichloromethane; 1: Addition / 2: Substitution;
DOI:10.1021/ja992109g