3-benzyl-3,4-dihydro-4-oxo-6-(2-chloro-ethyloxy)-7-methoxy-quinazoline

Base Information

• Chemical Name: 3-benzyl-3,4-dihydro-4-oxo-6-(2-chloro-ethyloxy)-7-methoxy-quinazoline
• CAS No.: 808793-60-4
• Molecular Formula: C₁₈H₁₇ClN₂O₃
• Molecular Weight: 344.798

Synonyms:3-benzyl-3,4-dihydro-4-oxo-6-(2-chloro-ethyloxy)-7-methoxy-quinazoline

Chemical Property of 3-benzyl-3,4-dihydro-4-oxo-6-(2-chloro-ethyloxy)-7-methoxy-quinazoline

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Technology Process of 3-benzyl-3,4-dihydro-4-oxo-6-(2-chloro-ethyloxy)-7-methoxy-quinazoline

There total 1 articles about 3-benzyl-3,4-dihydro-4-oxo-6-(2-chloro-ethyloxy)-7-methoxy-quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-benzyl-6-hydroxy-7-methoxy-3H-quinazolin-4-one (808793-56-8) + 2-chloroethyl tosylate (80-41-1) → 3-benzyl-3,4-dihydro-4-oxo-6-(2-chloro-ethyloxy)-7-methoxy-quinazoline (808793-60-4)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 40 - 45 ℃; for 24h;

Reference yield: 85.0%

3-benzyl-3,4-dihydro-4-oxo-6-(2-chloro-ethyloxy)-7-methoxy-quinazoline (808793-60-4) + (S)-1-amino-2-propanol (2799-17-9) → (S)-3-benzyl-3,4-dihydro-4-oxo-6-{2-[(2-hydroxypropyl)amino]ethyloxy}-7-methoxy-quinazoline (808793-59-1)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; sodium carbonate; at 135 - 140 ℃; for 2.41667h;

Reference yield: 41.0%

3-benzyl-3,4-dihydro-4-oxo-6-(2-chloro-ethyloxy)-7-methoxy-quinazoline (808793-60-4) + (S)-1-(benzylamino)propan-2-ol (357165-43-6) → (S)-3-benzyl-3,4-dihydro-4-oxo-6-{2-[N-(2-hydroxypropyl)-N-benzyl-amino]ethyloxy}-7-methoxy-quinazolin (808793-63-7)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; sodium carbonate; sodium iodide; at 125 ℃; for 4h;

upstream raw materials:

3-benzyl-6-hydroxy-7-methoxy-3H-quinazolin-4-one

2-chloroethyl tosylate

Downstream raw materials:

(S)-3-benzyl-3,4-dihydro-4-oxo-6-{2-[(2-hydroxypropyl)amino]ethyloxy}-7-methoxy-quinazoline

(S)-3-benzyl-3,4-dihydro-4-oxo-6-{2-[N-(2-hydroxypropyl)-N-benzyl-amino]ethyloxy}-7-methoxy-quinazolin

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