1-amino-5-(4-hydroxyphenyl)-9-(piperazin-1-yl)-3H-benzo[f]pyrazolo[3,4-c][2,7]naphthyridin-6(7H)-one hydrobromide

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Chemical Name:1-amino-5-(4-hydroxyphenyl)-9-(piperazin-1-yl)-3H-benzo[f]pyrazolo[3,4-c][2,7]naphthyridin-6(7H)-one hydrobromide
CAS No.:1403501-38-1
Molecular Formula:BrH*C₂₃H₂₁N₇O₂
Molecular Weight:508.377
Hs Code.:

Synonyms:1-amino-5-(4-hydroxyphenyl)-9-(piperazin-1-yl)-3H-benzo[f]pyrazolo[3,4-c][2,7]naphthyridin-6(7H)-one hydrobromide

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Chemical Property of 1-amino-5-(4-hydroxyphenyl)-9-(piperazin-1-yl)-3H-benzo[f]pyrazolo[3,4-c][2,7]naphthyridin-6(7H)-one hydrobromide

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Technology Process of 1-amino-5-(4-hydroxyphenyl)-9-(piperazin-1-yl)-3H-benzo[f]pyrazolo[3,4-c][2,7]naphthyridin-6(7H)-one hydrobromide

There total 7 articles about 1-amino-5-(4-hydroxyphenyl)-9-(piperazin-1-yl)-3H-benzo[f]pyrazolo[3,4-c][2,7]naphthyridin-6(7H)-one hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 67-56-1
methanol

: 1403501-13-2
tert-butyl 4-(1-amino-5-(4-methoxyphenyl)-6-oxo-6,7-dihydro-3H-benzo[f]pyrazolo[3,4-c][2,7]-naphthyridin-9-yl)piperazine-1-carboxylate

: 1403501-38-1
1-amino-5-(4-hydroxyphenyl)-9-(piperazin-1-yl)-3H-benzo[f]pyrazolo[3,4-c][2,7]naphthyridin-6(7H)-one hydrobromide

Guidance literature:: tert-butyl 4-(1-amino-5-(4-methoxyphenyl)-6-oxo-6,7-dihydro-3H-benzo[f]pyrazolo[3,4-c][2,7]-naphthyridin-9-yl)piperazine-1-carboxylate; With boron tribromide; In 1,2-dichloro-ethane; at -78 ℃; for 4h; Reflux;

methanol; In 1,2-dichloro-ethane; at 0 - 40 ℃; for 1h;

Reference yield:

: 1403501-08-5
tert-butyl 4-(4-(3-cyano-5-(ethoxycarbonyl)-6-(4-methoxyphenyl)-2-(methylthio)-1,4-dihydropyridine-4-yl)-3-nitrophenyl)piperazine-1-carboxylate

: 1403501-38-1
1-amino-5-(4-hydroxyphenyl)-9-(piperazin-1-yl)-3H-benzo[f]pyrazolo[3,4-c][2,7]naphthyridin-6(7H)-one hydrobromide

Guidance literature:: Multi-step reaction with 4 steps

1.1: manganese(II) oxide / dichloromethane / 60.5 h / 20 °C

2.1: acetic acid; iron / 4 h / 90 °C

3.1: hydrazine hydrate / dimethyl sulfoxide; butan-1-ol / 12 h / 150 °C

4.1: boron tribromide / 1,2-dichloro-ethane / 4 h / -78 °C / Reflux

4.2: 1 h / 0 - 40 °C

With manganese(II) oxide; boron tribromide; iron; hydrazine hydrate; acetic acid; In dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; butan-1-ol;

Reference yield:

: 1403501-09-6
tert-butyl 4-(4-(3-cyano-5-(ethoxycarbonyl)-6-(4-methoxyphenyl)-2-(methylthio)pyridin-4-yl)-3-nitrophenyl) piperazine-1-carboxylate

: 1403501-38-1
1-amino-5-(4-hydroxyphenyl)-9-(piperazin-1-yl)-3H-benzo[f]pyrazolo[3,4-c][2,7]naphthyridin-6(7H)-one hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; iron / 4 h / 90 °C

2.1: hydrazine hydrate / dimethyl sulfoxide; butan-1-ol / 12 h / 150 °C

3.1: boron tribromide / 1,2-dichloro-ethane / 4 h / -78 °C / Reflux

3.2: 1 h / 0 - 40 °C

With boron tribromide; iron; hydrazine hydrate; acetic acid; In dimethyl sulfoxide; 1,2-dichloro-ethane; butan-1-ol;