Technology Process of (S)-6-bromo-4'-methyl-1,2,3,4-tetrahydro-1,1'-biphenyl
There total 4 articles about (S)-6-bromo-4'-methyl-1,2,3,4-tetrahydro-1,1'-biphenyl which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
para-methylphenylmagnesium bromide;
With
copper(I) bromide dimethylsulfide complex;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
(R)-2-bromocyclohex-2-en-1-yl diethyl phosphate;
In
tetrahydrofuran;
at -40 - 0 ℃;
for 3h;
Overall yield = 82 %; Overall yield = 13.8 mg;
DOI:10.1055/s-0033-1341065
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: (S)-diphenylprolinol; Trimethyl borate; borane N,N-diethylaniline complex / tetrahydrofuran / 4 h / -10 - -2 °C
2.1: 1-methyl-1H-imidazole / dichloromethane / 4 h / 20 °C / Cooling with ice
3.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.5 h / 0 °C
3.2: 3 h / -40 - 0 °C
With
1-methyl-1H-imidazole; borane N,N-diethylaniline complex; copper(I) bromide dimethylsulfide complex; Trimethyl borate; (S)-diphenylprolinol;
In
tetrahydrofuran; dichloromethane;
DOI:10.1055/s-0033-1341065
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 1-methyl-1H-imidazole / dichloromethane / 4 h / 20 °C / Cooling with ice
2.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.5 h / 0 °C
2.2: 3 h / -40 - 0 °C
With
1-methyl-1H-imidazole; copper(I) bromide dimethylsulfide complex;
In
tetrahydrofuran; dichloromethane;
DOI:10.1055/s-0033-1341065
