tert-butyl (2S,5S)-1-benzyl-5-((S)-1-ethoxy-1-oxopent-4-en-2-yl)pyrrolidine-2-carboxylate

Base Information

Chemical Name:tert-butyl (2S,5S)-1-benzyl-5-((S)-1-ethoxy-1-oxopent-4-en-2-yl)pyrrolidine-2-carboxylate
CAS No.:1235568-27-0
Molecular Formula:C₂₃H₃₃NO₄
Molecular Weight:387.519
Hs Code.:

Synonyms:tert-butyl (2S,5S)-1-benzyl-5-((S)-1-ethoxy-1-oxopent-4-en-2-yl)pyrrolidine-2-carboxylate

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Chemical Property of tert-butyl (2S,5S)-1-benzyl-5-((S)-1-ethoxy-1-oxopent-4-en-2-yl)pyrrolidine-2-carboxylate

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Technology Process of tert-butyl (2S,5S)-1-benzyl-5-((S)-1-ethoxy-1-oxopent-4-en-2-yl)pyrrolidine-2-carboxylate

There total 1 articles about tert-butyl (2S,5S)-1-benzyl-5-((S)-1-ethoxy-1-oxopent-4-en-2-yl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1235568-24-7
tert-butyl (2S,5S)-1-benzyl-5-(2-ethoxycarbonylmethyl)pyrrolidine-2-carboxylate

: 106-95-6
allyl bromide

: 1235568-27-0
tert-butyl (2S,5S)-1-benzyl-5-((S)-1-ethoxy-1-oxopent-4-en-2-yl)pyrrolidine-2-carboxylate

Guidance literature:: tert-butyl (2S,5S)-1-benzyl-5-(2-ethoxycarbonylmethyl)pyrrolidine-2-carboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.75h; Inert atmosphere;

allyl bromide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; toluene; at -78 ℃; for 0.666667h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/jo1008433

Reference yield: 94.0%

: 1235568-27-0
tert-butyl (2S,5S)-1-benzyl-5-((S)-1-ethoxy-1-oxopent-4-en-2-yl)pyrrolidine-2-carboxylate

: 1235568-42-9
(S)-2-((2S,5S)-1-benzyl-5-(tert-butoxycarbonyl)pyrrolidin-2-yl)-pent-4-enoic acid

Guidance literature:: tert-butyl (2S,5S)-1-benzyl-5-((S)-1-ethoxy-1-oxopent-4-en-2-yl)pyrrolidine-2-carboxylate; With tetra(n-butyl)ammonium hydroxide; sodium hydroxide; In methanol; water; at 50 ℃; for 24h; Inert atmosphere;

With hydrogenchloride; In water; pH=3;
DOI:10.1021/jo1008433

Reference yield:

: 2495-35-4,25036-21-9
benzylacrylate

: 1235568-27-0
tert-butyl (2S,5S)-1-benzyl-5-((S)-1-ethoxy-1-oxopent-4-en-2-yl)pyrrolidine-2-carboxylate

: 1-benzyl 6-ethyl (S)-5-((2S,5S)-1-benzyl-5-(tert-butoxycarbonyl)-pyrrolidin-2-yl)hex-2-enedioate

: 1235568-38-3
1-benzyl 6-ethyl (S)-5-((2S,5S)-1-benzyl-5-(tert-butoxycarbonyl)-pyrrolidin-2-yl)hex-2-enedioate

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In 1,2-dichloro-ethane; at 65 ℃; for 24h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/jo1008433