tert-butyl (2S,5S)-1-benzyl-5-(2-ethoxycarbonylmethyl)pyrrolidine-2-carboxylate

Base Information

Chemical Name:tert-butyl (2S,5S)-1-benzyl-5-(2-ethoxycarbonylmethyl)pyrrolidine-2-carboxylate
CAS No.:1235568-24-7
Molecular Formula:C₂₀H₂₉NO₄
Molecular Weight:347.455
Hs Code.:

Synonyms:tert-butyl (2S,5S)-1-benzyl-5-(2-ethoxycarbonylmethyl)pyrrolidine-2-carboxylate

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Chemical Property of tert-butyl (2S,5S)-1-benzyl-5-(2-ethoxycarbonylmethyl)pyrrolidine-2-carboxylate

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Technology Process of tert-butyl (2S,5S)-1-benzyl-5-(2-ethoxycarbonylmethyl)pyrrolidine-2-carboxylate

There total 1 articles about tert-butyl (2S,5S)-1-benzyl-5-(2-ethoxycarbonylmethyl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂HF₃O₂*C₁₃H₂₃NO₄

: 100-39-0
benzyl bromide

: 1235568-24-7
tert-butyl (2S,5S)-1-benzyl-5-(2-ethoxycarbonylmethyl)pyrrolidine-2-carboxylate

Guidance literature:: With potassium carbonate; In acetone; for 24h; Inert atmosphere;
DOI:10.1021/jo1008433

Reference yield: 95.0%

: 1235568-24-7
tert-butyl (2S,5S)-1-benzyl-5-(2-ethoxycarbonylmethyl)pyrrolidine-2-carboxylate

: 106-95-6
allyl bromide

: 1235568-27-0
tert-butyl (2S,5S)-1-benzyl-5-((S)-1-ethoxy-1-oxopent-4-en-2-yl)pyrrolidine-2-carboxylate

Guidance literature:: tert-butyl (2S,5S)-1-benzyl-5-(2-ethoxycarbonylmethyl)pyrrolidine-2-carboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.75h; Inert atmosphere;

allyl bromide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; toluene; at -78 ℃; for 0.666667h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/jo1008433

Reference yield: 84.0%

: 1235568-24-7
tert-butyl (2S,5S)-1-benzyl-5-(2-ethoxycarbonylmethyl)pyrrolidine-2-carboxylate

: 1235568-25-8
tert-butyl (2S,5S)-5-((S)-1-azido-2-ethoxycarbonylmethyl)-1-benzylpyrrolidine-2-carboxylate

Guidance literature:: tert-butyl (2S,5S)-1-benzyl-5-(2-ethoxycarbonylmethyl)pyrrolidine-2-carboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.75h; Inert atmosphere;

With 2,4,6-Triisopropylbenzenesulfonyl azide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; toluene; at -78 ℃; optical yield given as %de; Inert atmosphere;
DOI:10.1021/jo1008433