α-amino-4-(phenylmethoxy)benzeneacetic acid phenylmethyl ester HCl

Base Information

• Chemical Name: α-amino-4-(phenylmethoxy)benzeneacetic acid phenylmethyl ester HCl
• CAS No.: 75986-02-6
• Molecular Formula: C₂₂H₂₁NO₃*ClH
• Molecular Weight: 383.875
• Mol file: 75986-02-6.mol

Synonyms:α-amino-4-(phenylmethoxy)benzeneacetic acid phenylmethyl ester HCl

Chemical Property of α-amino-4-(phenylmethoxy)benzeneacetic acid phenylmethyl ester HCl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-amino-4-(phenylmethoxy)benzeneacetic acid phenylmethyl ester HCl

There total 4 articles about α-amino-4-(phenylmethoxy)benzeneacetic acid phenylmethyl ester HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.3%

benzyl N-t-butoxycarbonyl-p-benzyloxyphenylglycinate (76023-83-1) → α-amino-4-(phenylmethoxy)benzeneacetic acid phenylmethyl ester HCl (75986-02-6)

Guidance literature:

With hydrogenchloride; In dichloromethane; for 0.333333h;

DOI:10.1016/S0040-4020(01)96430-0

Reference yield:

benzyl bromide (100-39-0) → α-amino-4-(phenylmethoxy)benzeneacetic acid phenylmethyl ester HCl (75986-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 81.5 percent / K₂CO₃

2: 91.3 percent / HCl(g) / CH₂Cl₂

With hydrogenchloride; potassium carbonate; In dichloromethane;

DOI:10.1039/c39800000770

Reference yield:

p-hydroxyphenylglycine (6324-01-2) → α-amino-4-(phenylmethoxy)benzeneacetic acid phenylmethyl ester HCl (75986-02-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 81.7 percent

2: 81.5 percent / K₂CO₃

3: 91.3 percent / HCl(g) / CH₂Cl₂

With hydrogenchloride; potassium carbonate; In dichloromethane;

DOI:10.1039/c39800000770

upstream raw materials:

benzyl N-t-butoxycarbonyl-p-benzyloxyphenylglycinate

benzyl bromide

p-hydroxyphenylglycine

N-t-butoxycarbonyl-p-hydroxyphenylglycine

Downstream raw materials:

benzyl N-(2-bromo-2-propenyl)-p-benzyloxyphenylglycinate

Benzyl (+/-)-(αR^*,3S^*)-3-Amino-α--2-oxo-1-azetidineacetate Hydrotosylate

Benzyl (+/-)-(αR^*,3R^*)-3-Amino-α--2-oxo-1-azetidineacetate Hydrotosylate

(+/-)-dibenzyl 3-ANA

Refernces

• 1、 Chiba, Katsumi,Mori, Miwako,Ban, Yoshio. "A Novel Synthesis of (+/-)-3-Aminonocardinic Acid". . p. 770 - 772. Retrieved 2007/10/02.