Technology Process of (2S)-N,N'-bis-(phenylsulfonyl)-3-(2-pyrrolyl)alaninol
There total 5 articles about (2S)-N,N'-bis-(phenylsulfonyl)-3-(2-pyrrolyl)alaninol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
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Multi-step reaction with 4 steps
1: 18-crown-6 ether; potassium tert-butylate / tetrahydrofuran / 0 °C
2: water; acetic acid / 50 °C
3: trifluoroacetic acid / dichloromethane
4: sodium carbonate / 1,4-dioxane; water
With
18-crown-6 ether; potassium tert-butylate; water; sodium carbonate; acetic acid; trifluoroacetic acid;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.tetlet.2010.11.089
- Guidance literature:
-
Multi-step reaction with 3 steps
1: water; acetic acid / 50 °C
2: trifluoroacetic acid / dichloromethane
3: sodium carbonate / 1,4-dioxane; water
With
water; sodium carbonate; acetic acid; trifluoroacetic acid;
In
1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.tetlet.2010.11.089
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide / 1,4-dioxane; water
2: ammonium formate; sodium acetate; acetic acid / acetonitrile / 65 °C
3: 18-crown-6 ether; potassium tert-butylate / tetrahydrofuran / 0 °C
4: water; acetic acid / 50 °C
5: trifluoroacetic acid / dichloromethane
6: sodium carbonate / 1,4-dioxane; water
With
2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; 18-crown-6 ether; potassium tert-butylate; water; ammonium formate; sodium acetate; sodium carbonate; acetic acid; trifluoroacetic acid;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;
2: Paal-Knorr condensation;
DOI:10.1016/j.tetlet.2010.11.089
