N,N'-bis-(phenylsulfonyl)-3-(2-pyrrolyl)alaninyl-proline N'-methylamide

Base Information

Chemical Name:N,N'-bis-(phenylsulfonyl)-3-(2-pyrrolyl)alaninyl-proline N'-methylamide
CAS No.:1262660-98-9
Molecular Formula:C₂₅H₂₈N₄O₆S₂
Molecular Weight:544.653
Hs Code.:

Synonyms:N,N'-bis-(phenylsulfonyl)-3-(2-pyrrolyl)alaninyl-proline N'-methylamide

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Chemical Property of N,N'-bis-(phenylsulfonyl)-3-(2-pyrrolyl)alaninyl-proline N'-methylamide

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Technology Process of N,N'-bis-(phenylsulfonyl)-3-(2-pyrrolyl)alaninyl-proline N'-methylamide

There total 8 articles about N,N'-bis-(phenylsulfonyl)-3-(2-pyrrolyl)alaninyl-proline N'-methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1262660-97-8
(2S)-N,N'-bis-(phenylsulfonyl)-3-(2-pyrrolyl)alanine

: 33208-98-9
pyrrolidine-2-carboxylic acid methylamide hydrochloride

: 1262660-98-9
N,N'-bis-(phenylsulfonyl)-3-(2-pyrrolyl)alaninyl-proline N'-methylamide

Guidance literature:: With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 ℃;
DOI:10.1016/j.tetlet.2010.11.089

Reference yield:

: C₁₃H₁₆N₂O₃S

: 1262660-98-9
N,N'-bis-(phenylsulfonyl)-3-(2-pyrrolyl)alaninyl-proline N'-methylamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / 1,4-dioxane; water

2: sodium chlorite; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 35 °C / sodium-phosphate buffer

3: benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / acetonitrile / 0 °C

With sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium carbonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; acetonitrile;
DOI:10.1016/j.tetlet.2010.11.089

Reference yield:

: 1262660-96-7
(2S)-N,N'-bis-(phenylsulfonyl)-3-(2-pyrrolyl)alaninol

: 1262660-98-9
N,N'-bis-(phenylsulfonyl)-3-(2-pyrrolyl)alaninyl-proline N'-methylamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium chlorite; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 35 °C / sodium-phosphate buffer

2: benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / acetonitrile / 0 °C

With sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In acetonitrile;
DOI:10.1016/j.tetlet.2010.11.089