(2S)-2-(2-bromoisonicotinoylamino)-3-(3,4-dimethoxyphenyl)-1-propanol

Base Information

• Chemical Name: (2S)-2-(2-bromoisonicotinoylamino)-3-(3,4-dimethoxyphenyl)-1-propanol
• CAS No.: 209262-38-4
• Molecular Formula: C₁₇H₁₉BrN₂O₄
• Molecular Weight: 395.253
• Mol file: 209262-38-4.mol

Synonyms:(2S)-2-(2-bromoisonicotinoylamino)-3-(3,4-dimethoxyphenyl)-1-propanol

Chemical Property of (2S)-2-(2-bromoisonicotinoylamino)-3-(3,4-dimethoxyphenyl)-1-propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-2-(2-bromoisonicotinoylamino)-3-(3,4-dimethoxyphenyl)-1-propanol

There total 4 articles about (2S)-2-(2-bromoisonicotinoylamino)-3-(3,4-dimethoxyphenyl)-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromoisonicotinic acid (66572-56-3) → (2S)-2-(2-bromoisonicotinoylamino)-3-(3,4-dimethoxyphenyl)-1-propanol (209262-38-4)

Guidance literature:

Multi-step reaction with 2 steps

1: DCC; HOBt / CH₂Cl₂ / 25 °C

2: NaBH₄; MeOH / tetrahydrofuran / Heating

With methanol; sodium tetrahydroborate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0960-894X(03)00438-4

Reference yield:

(2S)-1-(2-bromoisonicotinoyloxy)-2-(2-bromoisonicotinoylamino)-3-(3,4-dimethoxyphenyl)propane → (2S)-2-(2-bromoisonicotinoylamino)-3-(3,4-dimethoxyphenyl)-1-propanol (209262-38-4)

Guidance literature:

With lithium hydroxide; In methanol;

Reference yield:

N-(2-bromoisonicotinoyl)-3-(3,4-dimethoxyphenyl)-L-alanine ethyl ester (259817-68-0) → (2S)-2-(2-bromoisonicotinoylamino)-3-(3,4-dimethoxyphenyl)-1-propanol (209262-38-4)

Guidance literature:

With methanol; sodium tetrahydroborate; In tetrahydrofuran; Heating;

DOI:10.1016/S0960-894X(03)00438-4

upstream raw materials:

N-(2-bromoisonicotinoyl)-3-(3,4-dimethoxyphenyl)-L-alanine ethyl ester

2-bromoisonicotinic acid

(S)-(+)-3,4-dimethoxyphenylalanine ethyl ester hydrochloride

Downstream raw materials:

N-[2-(3,4-dimethoxy-phenyl)-1-hydroxymethyl-ethyl]-2-(1-oxo-4-pyrimidin-5-yl-1H-phthalazin-2-yl)-isonicotinamide

(2S)-2-{2-[4-(3-pyridyl)phthalazin-1(2H)-on-2-yl]isonicotinoylamino}-3-(3,4-dimethoxyphenyl)-1-propanol

N-[2-(3,4-dimethoxy-phenyl)-1-hydroxymethyl-ethyl]-2-(1-oxo-4-pyridin-3-ylmethyl-1H-phthalazin-2-yl)-isonicotinamide

acetic acid 3-(3,4-dimethoxy-phenyl)-2-{[2-(1-oxo-4-pyridin-3-ylmethyl-1H-phthalazin-2-yl)-pyridine-4-carbonyl]-amino}-propyl ester