3β-(4-methylphenyl)tropane-2β-N-(3,4-dichlorophenacyl)carboxamide ethylene ketal

Base Information

Chemical Name:3β-(4-methylphenyl)tropane-2β-N-(3,4-dichlorophenacyl)carboxamide ethylene ketal
CAS No.:947595-17-7
Molecular Formula:C₂₆H₃₀Cl₂N₂O₃
Molecular Weight:489.442
Hs Code.:

Synonyms:3β-(4-methylphenyl)tropane-2β-N-(3,4-dichlorophenacyl)carboxamide ethylene ketal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3β-(4-methylphenyl)tropane-2β-N-(3,4-dichlorophenacyl)carboxamide ethylene ketal

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Technology Process of 3β-(4-methylphenyl)tropane-2β-N-(3,4-dichlorophenacyl)carboxamide ethylene ketal

There total 4 articles about 3β-(4-methylphenyl)tropane-2β-N-(3,4-dichlorophenacyl)carboxamide ethylene ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 889140-40-3
3,4-dichlorophenacylamine ethylene ketal

: 141807-59-2
8-methyl-3S-p-tolyl-8-azabicyclo[3.2.1]octane-2S-carboxylic acid

: 947595-17-7
3β-(4-methylphenyl)tropane-2β-N-(3,4-dichlorophenacyl)carboxamide ethylene ketal

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 25 ℃;
DOI:10.1021/jm0703035

Reference yield:

: 947594-73-2
3,4-dichlorophenacyl azide ethylene ketal

: 947595-17-7
3β-(4-methylphenyl)tropane-2β-N-(3,4-dichlorophenacyl)carboxamide ethylene ketal

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine / tetrahydrofuran

1.2: 95 percent / water / tetrahydrofuran

2.1: 67 percent / 1-hydroxy-7-azabenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / 25 °C

With 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Staudinger reaction;
DOI:10.1021/jm0703035

Reference yield:

: 2632-10-2
2-bromo-1-(3,4-dichlorophenyl)ethanone

: 947595-17-7
3β-(4-methylphenyl)tropane-2β-N-(3,4-dichlorophenacyl)carboxamide ethylene ketal

Guidance literature:: Multi-step reaction with 4 steps

1.1: 48 percent / sodium azide / dimethylsulfoxide / 20 °C

2.1: 71 percent / boron trifluoride etherate / CH₂Cl₂ / 20 °C

3.1: triphenylphosphine / tetrahydrofuran

3.2: 95 percent / water / tetrahydrofuran

4.1: 67 percent / 1-hydroxy-7-azabenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / 25 °C

With sodium azide; 1-hydroxy-7-aza-benzotriazole; boron trifluoride diethyl etherate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triphenylphosphine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 3.1: Staudinger reaction;
DOI:10.1021/jm0703035