Boc-L-Phe-NH(CH₂)2NHMe

Base Information

Chemical Name:Boc-L-Phe-NH(CH₂)2NHMe
CAS No.:210818-40-9
Molecular Formula:C₁₇H₂₇N₃O₃
Molecular Weight:321.42
Hs Code.:

Synonyms:Boc-L-Phe-NH(CH₂)2NHMe

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Chemical Property of Boc-L-Phe-NH(CH₂)2NHMe

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Technology Process of Boc-L-Phe-NH(CH₂)2NHMe

There total 1 articles about Boc-L-Phe-NH(CH₂)2NHMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 142955-51-9
N-butoxycarbonyl-L-phenylalanine anhydride

: 109-81-9
N-methyl-ethane-1,2-diamine

: 210818-40-9
Boc-L-Phe-NH(CH₂)2NHMe

Guidance literature:: In dichloromethane; for 1.5h; Ambient temperature;
DOI:10.1021/jm970861r

Reference yield:

: 210818-40-9
Boc-L-Phe-NH(CH₂)2NHMe

: {(R)-3-{[2-((S)-2-Amino-3-phenyl-propionylamino)-ethyl]-methyl-amino}-2-[(S)-2-benzyloxycarbonylamino-3-(4-benzyloxy-phenyl)-propionylamino]-propionylamino}-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Cs₂CO₃, 2.) BOP / 1.) DMF, RT, 24 h, 2.) DMF, RT, 52 h

2: H₂ / 10percent Pd/C / ethanol / 19 h

3: DIEA, BOP / dimethylformamide / 48 h

4: TFA / CH₂Cl₂ / 1 h

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970861r

Reference yield:

: 210818-40-9
Boc-L-Phe-NH(CH₂)2NHMe

: 210818-43-2
[(S)-1-((6S,12R)-6-Benzyl-1-methyl-5,8,11-trioxo-1,4,7,10-tetraaza-cyclotridec-12-ylcarbamoyl)-2-(4-benzyloxy-phenyl)-ethyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Cs₂CO₃, 2.) BOP / 1.) DMF, RT, 24 h, 2.) DMF, RT, 52 h

2: H₂ / 10percent Pd/C / ethanol / 19 h

3: DIEA, BOP / dimethylformamide / 48 h

4: TFA / CH₂Cl₂ / 1 h

5: 49 percent / HOAt, DIEA, EDC / dimethylformamide; CH₂Cl₂ / 168 h

With 1-hydroxy-7-aza-benzotriazole; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970861r