[3-(3-Benzyloxycarbonylaminocarbonyl-2-methyl-isothioureido)-2-(benzyloxycarbonyl-methyl-amino)-3-oxo-propyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[3-(3-Benzyloxycarbonylaminocarbonyl-2-methyl-isothioureido)-2-(benzyloxycarbonyl-methyl-amino)-3-oxo-propyl]-carbamic acid tert-butyl ester
CAS No.:198416-03-4
Molecular Formula:C₂₈H₃₅N₅O₈S
Molecular Weight:601.681
Hs Code.:

[3-(3-Benzyloxycarbonylaminocarbonyl-2-methyl-isothioureido)-2-(benzyloxycarbonyl-methyl-amino)-3-oxo-propyl]-carbamic acid tert-butyl ester

Synonyms:[3-(3-Benzyloxycarbonylaminocarbonyl-2-methyl-isothioureido)-2-(benzyloxycarbonyl-methyl-amino)-3-oxo-propyl]-carbamic acid tert-butyl ester

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Chemical Property of [3-(3-Benzyloxycarbonylaminocarbonyl-2-methyl-isothioureido)-2-(benzyloxycarbonyl-methyl-amino)-3-oxo-propyl]-carbamic acid tert-butyl ester

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Technology Process of [3-(3-Benzyloxycarbonylaminocarbonyl-2-methyl-isothioureido)-2-(benzyloxycarbonyl-methyl-amino)-3-oxo-propyl]-carbamic acid tert-butyl ester

There total 6 articles about [3-(3-Benzyloxycarbonylaminocarbonyl-2-methyl-isothioureido)-2-(benzyloxycarbonyl-methyl-amino)-3-oxo-propyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 198416-02-3
(2-Methyl-isothioureidocarbonyl)-carbamic acid benzyl ester

: 198416-01-2
2-(N-benzyloxycarbonyl-N-methyl)amino-3-(tert-butoxycarbonylamino)propionic acid

: 198416-03-4
[3-(3-Benzyloxycarbonylaminocarbonyl-2-methyl-isothioureido)-2-(benzyloxycarbonyl-methyl-amino)-3-oxo-propyl]-carbamic acid tert-butyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; Ambient temperature;
DOI:10.1021/ja972670j

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 198416-03-4
[3-(3-Benzyloxycarbonylaminocarbonyl-2-methyl-isothioureido)-2-(benzyloxycarbonyl-methyl-amino)-3-oxo-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 32 percent / aq. NaOH

2: 41 percent / 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride, DMAP / CH₂Cl₂ / Ambient temperature

With dmap; sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/ja972670j

Reference yield:

: 69032-16-2
benzyloxycarbonyl isocyanate

: 198416-03-4
[3-(3-Benzyloxycarbonylaminocarbonyl-2-methyl-isothioureido)-2-(benzyloxycarbonyl-methyl-amino)-3-oxo-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / tetrahydrofuran / 0.17 h / Ambient temperature

2: CF₃COOH / 0.5 h / Ambient temperature

3: 41 percent / 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride, DMAP / CH₂Cl₂ / Ambient temperature

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja972670j