2-(4-fluorophenyl)-6-(hexahydropyrrolo[3,4-c]pyrrol-2-(1H)-yl)-3-(pyridazin-4-yl)-imidazo[1,2-b]pyridazine

Base Information

Chemical Name:2-(4-fluorophenyl)-6-(hexahydropyrrolo[3,4-c]pyrrol-2-(1H)-yl)-3-(pyridazin-4-yl)-imidazo[1,2-b]pyridazine
CAS No.:1105714-32-6
Molecular Formula:C₂₂H₂₀FN₇
Molecular Weight:401.446
Hs Code.:

Synonyms:2-(4-fluorophenyl)-6-(hexahydropyrrolo[3,4-c]pyrrol-2-(1H)-yl)-3-(pyridazin-4-yl)-imidazo[1,2-b]pyridazine

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Chemical Property of 2-(4-fluorophenyl)-6-(hexahydropyrrolo[3,4-c]pyrrol-2-(1H)-yl)-3-(pyridazin-4-yl)-imidazo[1,2-b]pyridazine

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Technology Process of 2-(4-fluorophenyl)-6-(hexahydropyrrolo[3,4-c]pyrrol-2-(1H)-yl)-3-(pyridazin-4-yl)-imidazo[1,2-b]pyridazine

There total 4 articles about 2-(4-fluorophenyl)-6-(hexahydropyrrolo[3,4-c]pyrrol-2-(1H)-yl)-3-(pyridazin-4-yl)-imidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1105714-36-0
6-(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-(1H)-yl)-2-(4-fluorophenyl)-3-pyridazin-4-ylimidazo[1,2-b]pyridazine

: 1105714-32-6
2-(4-fluorophenyl)-6-(hexahydropyrrolo[3,4-c]pyrrol-2-(1H)-yl)-3-(pyridazin-4-yl)-imidazo[1,2-b]pyridazine

Guidance literature:: With ammonium formate; palladium 10% on activated carbon; In methanol; for 2h; Reflux;

Reference yield:

: 1105714-45-1
Ethyl 4-[6-chloro-2-(4-fluorophenyl)-imidazo[1,2-b]pyridazin-3-yl]-4H-pyridazine-1-carboxylate

: 1105714-32-6
2-(4-fluorophenyl)-6-(hexahydropyrrolo[3,4-c]pyrrol-2-(1H)-yl)-3-(pyridazin-4-yl)-imidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: o-tetrachloroquinone / toluene / 0.5 h / 20 °C

2: pentan-1-ol / 18 h / 150 °C / Sealed tube

3: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Reflux

With o-tetrachloroquinone; ammonium formate; palladium 10% on activated carbon; In methanol; pentan-1-ol; toluene;

Reference yield:

: 244081-70-7
6-Chloro-2-(4-fluorophenyl)imidazo[1,2-b]pyridazine

: 1105714-32-6
2-(4-fluorophenyl)-6-(hexahydropyrrolo[3,4-c]pyrrol-2-(1H)-yl)-3-(pyridazin-4-yl)-imidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 4.5 h / 10 °C

2: o-tetrachloroquinone / toluene / 0.5 h / 20 °C

3: pentan-1-ol / 18 h / 150 °C / Sealed tube

4: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Reflux

With o-tetrachloroquinone; ammonium formate; palladium 10% on activated carbon; In methanol; dichloromethane; pentan-1-ol; toluene;