Ethyl 4-[6-chloro-2-(4-fluorophenyl)-imidazo[1,2-b]pyridazin-3-yl]-4H-pyridazine-1-carboxylate

Base Information

Chemical Name:Ethyl 4-[6-chloro-2-(4-fluorophenyl)-imidazo[1,2-b]pyridazin-3-yl]-4H-pyridazine-1-carboxylate
CAS No.:1105714-45-1
Molecular Formula:C₁₉H₁₅ClFN₅O₂
Molecular Weight:399.812
Hs Code.:

Synonyms:Ethyl 4-[6-chloro-2-(4-fluorophenyl)-imidazo[1,2-b]pyridazin-3-yl]-4H-pyridazine-1-carboxylate

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Chemical Property of Ethyl 4-[6-chloro-2-(4-fluorophenyl)-imidazo[1,2-b]pyridazin-3-yl]-4H-pyridazine-1-carboxylate

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Technology Process of Ethyl 4-[6-chloro-2-(4-fluorophenyl)-imidazo[1,2-b]pyridazin-3-yl]-4H-pyridazine-1-carboxylate

There total 1 articles about Ethyl 4-[6-chloro-2-(4-fluorophenyl)-imidazo[1,2-b]pyridazin-3-yl]-4H-pyridazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 289-80-5
1,2-diazine

: 541-41-3
chloroformic acid ethyl ester

: 244081-70-7
6-Chloro-2-(4-fluorophenyl)imidazo[1,2-b]pyridazine

: 1105714-45-1
Ethyl 4-[6-chloro-2-(4-fluorophenyl)-imidazo[1,2-b]pyridazin-3-yl]-4H-pyridazine-1-carboxylate

Guidance literature:: In dichloromethane; at 10 ℃; for 4.5h;

Reference yield:

: 1105714-45-1
Ethyl 4-[6-chloro-2-(4-fluorophenyl)-imidazo[1,2-b]pyridazin-3-yl]-4H-pyridazine-1-carboxylate

: 1105714-46-2
6-chloro-2-(4-fluorophenyl)-3-(pyridazin-4-yl)-imidazo[1,2-b]pyridazine

Guidance literature:: Ethyl 4-[6-chloro-2-(4-fluorophenyl)-imidazo[1,2-b]pyridazin-3-yl]-4H-pyridazine-1-carboxylate; With o-tetrachloroquinone; In toluene; at 20 ℃; for 0.5h;

With sodium hydroxide; In water; toluene;

Reference yield:

: 1105714-45-1
Ethyl 4-[6-chloro-2-(4-fluorophenyl)-imidazo[1,2-b]pyridazin-3-yl]-4H-pyridazine-1-carboxylate

: 1105714-32-6
2-(4-fluorophenyl)-6-(hexahydropyrrolo[3,4-c]pyrrol-2-(1H)-yl)-3-(pyridazin-4-yl)-imidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: o-tetrachloroquinone / toluene / 0.5 h / 20 °C

2: pentan-1-ol / 18 h / 150 °C / Sealed tube

3: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Reflux

With o-tetrachloroquinone; ammonium formate; palladium 10% on activated carbon; In methanol; pentan-1-ol; toluene;