(αR)-α-hydroxy-3,5-dimethyl-4-(phenylmethoxy)-phenylpropionic acid monosodium salt

Base Information

Chemical Name:(αR)-α-hydroxy-3,5-dimethyl-4-(phenylmethoxy)-phenylpropionic acid monosodium salt
CAS No.:1007587-75-8
Molecular Formula:C₁₈H₁₉O₄*Na
Molecular Weight:322.336
Hs Code.:

Synonyms:(αR)-α-hydroxy-3,5-dimethyl-4-(phenylmethoxy)-phenylpropionic acid monosodium salt

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Chemical Property of (αR)-α-hydroxy-3,5-dimethyl-4-(phenylmethoxy)-phenylpropionic acid monosodium salt

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Technology Process of (αR)-α-hydroxy-3,5-dimethyl-4-(phenylmethoxy)-phenylpropionic acid monosodium salt

There total 4 articles about (αR)-α-hydroxy-3,5-dimethyl-4-(phenylmethoxy)-phenylpropionic acid monosodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1310-73-2
sodium hydroxide

: (αR)-α-hydroxy-3,5-dimethyl-4-(phenylmethoxy)-phenylpropionic acid-monosodium salt

: 1007587-75-8
(αR)-α-hydroxy-3,5-dimethyl-4-(phenylmethoxy)-phenylpropionic acid monosodium salt

Guidance literature:: (2E)-3-[3,5-dimethyl-4-(phenylmethoxy)phenyl]-2-hydroxy-2-propenoic acid; With triethylamine; (-)-diisopinocamphenylborane chloride; In 2-methyltetrahydrofuran; hexane; at -30 - 0 ℃; for 2h;

With hydrogenchloride; In 2-methyltetrahydrofuran; hexane; water; ethyl acetate;

sodium hydroxide; In tert-butyl methyl ether; water; at 0 ℃; for 1h;

Reference yield:

: 773129-38-7
C₁₈H₁₈O₃

: 1007587-75-8
(αR)-α-hydroxy-3,5-dimethyl-4-(phenylmethoxy)-phenylpropionic acid monosodium salt

Guidance literature:: C₁₈H₁₈O₃; With triethylamine; chlorobis(2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)borane; In n-heptane; toluene; at -5 - 20 ℃; for 1h; Industrial scale;

With sodium hydroxide; In n-heptane; water; toluene; at 70 ℃; Product distribution / selectivity; Industrial scale;

Reference yield:

: 1117699-25-8
(2Z)-3-(4-benzyloxy-3,5-dimethyl-phenyl)-2-(tetrahydro-pyran-2-yloxy)acrylic acid monopotassium salt

: 1007587-75-8
(αR)-α-hydroxy-3,5-dimethyl-4-(phenylmethoxy)-phenylpropionic acid monosodium salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanesulfonic acid / toluene / -5 - 5 °C / Industrial scale

2.1: triethylamine; chlorobis(2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)borane / n-heptane; toluene / 1 h / -5 - 20 °C / Industrial scale

2.2: 70 °C / Industrial scale

With methanesulfonic acid; triethylamine; chlorobis(2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)borane; In n-heptane; toluene;