ethyl (2Z)-3-(4-benzyloxy-3,5-dimethyl-phenyl)-2-(tetrahydropyran-2-yloxy)acrylate

Base Information

• Chemical Name: ethyl (2Z)-3-(4-benzyloxy-3,5-dimethyl-phenyl)-2-(tetrahydropyran-2-yloxy)acrylate
• CAS No.: 1117699-24-7
• Molecular Formula: C₂₅H₃₀O₅
• Molecular Weight: 410.51

Synonyms:ethyl (2Z)-3-(4-benzyloxy-3,5-dimethyl-phenyl)-2-(tetrahydropyran-2-yloxy)acrylate

Chemical Property of ethyl (2Z)-3-(4-benzyloxy-3,5-dimethyl-phenyl)-2-(tetrahydropyran-2-yloxy)acrylate

Chemical Property:

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Technology Process of ethyl (2Z)-3-(4-benzyloxy-3,5-dimethyl-phenyl)-2-(tetrahydropyran-2-yloxy)acrylate

There total 2 articles about ethyl (2Z)-3-(4-benzyloxy-3,5-dimethyl-phenyl)-2-(tetrahydropyran-2-yloxy)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

ethyl (tetrahydropyranyloxy)acetate (61675-94-3) + 3,5-dimethyl-4-benzyloxy benzaldehyde (144896-51-5) → ethyl (2Z)-3-(4-benzyloxy-3,5-dimethyl-phenyl)-2-(tetrahydropyran-2-yloxy)acrylate (1117699-24-7)

Guidance literature:

With potassium 2-methylbutan-2-olate; In tetrahydrofuran; at 20 ℃; Product distribution / selectivity; Industrial scale;

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → ethyl (2Z)-3-(4-benzyloxy-3,5-dimethyl-phenyl)-2-(tetrahydropyran-2-yloxy)acrylate (1117699-24-7)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 20 °C / Industrial scale

2: potassium 2-methylbutan-2-olate / tetrahydrofuran / 20 °C / Industrial scale

With potassium 2-methylbutan-2-olate; toluene-4-sulfonic acid; In tetrahydrofuran; toluene;

Reference yield: 99.0%

ethyl (2Z)-3-(4-benzyloxy-3,5-dimethyl-phenyl)-2-(tetrahydropyran-2-yloxy)acrylate (1117699-24-7) → (2Z)-3-(4-benzyloxy-3,5-dimethyl-phenyl)-2-(tetrahydro-pyran-2-yloxy)acrylic acid monopotassium salt (1117699-25-8)

Guidance literature:

With potassium hydroxide; In tert-Amyl alcohol; for 1h; Product distribution / selectivity; Reflux; Industrial scale;

upstream raw materials:

3,4-dihydro-2H-pyran

ethyl (tetrahydropyranyloxy)acetate

3,5-dimethyl-4-benzyloxy benzaldehyde

Downstream raw materials:

4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-2-(4-benzyloxy-3,5-dimethyl-phenyl)-1-carboxy-ethyl ester

(αR)-α-hydroxy-3,5-dimethyl-4-(phenylmethoxy)-phenylpropionic acid monosodium salt

(2Z)-3-(4-benzyloxy-3,5-dimethyl-phenyl)-2-(tetrahydro-pyran-2-yloxy)acrylic acid monopotassium salt

C₁₈H₁₈O₃

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