2-(4-fluorophenyl)-5-(5-(isobutylcarbamoyl)-2-isopropoxyphenyl)-N-methylbenzofuran-3-carboxamide

Base Information

Chemical Name:2-(4-fluorophenyl)-5-(5-(isobutylcarbamoyl)-2-isopropoxyphenyl)-N-methylbenzofuran-3-carboxamide
CAS No.:1217334-47-8
Molecular Formula:C₃₀H₃₁FN₂O₄
Molecular Weight:502.586
Hs Code.:

Synonyms:2-(4-fluorophenyl)-5-(5-(isobutylcarbamoyl)-2-isopropoxyphenyl)-N-methylbenzofuran-3-carboxamide

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Chemical Property of 2-(4-fluorophenyl)-5-(5-(isobutylcarbamoyl)-2-isopropoxyphenyl)-N-methylbenzofuran-3-carboxamide

Chemical Property:

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Technology Process of 2-(4-fluorophenyl)-5-(5-(isobutylcarbamoyl)-2-isopropoxyphenyl)-N-methylbenzofuran-3-carboxamide

There total 5 articles about 2-(4-fluorophenyl)-5-(5-(isobutylcarbamoyl)-2-isopropoxyphenyl)-N-methylbenzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1217333-67-9
2-(4-fluorophenyl)-5-(2-hydroxy-5-(isobutylcarbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide

: 75-26-3
isopropyl bromide

: 1217334-47-8
2-(4-fluorophenyl)-5-(5-(isobutylcarbamoyl)-2-isopropoxyphenyl)-N-methylbenzofuran-3-carboxamide

Guidance literature:: In N,N-dimethyl-formamide; at 22 - 70 ℃; Alkaline conditions; Sealed tube;

Reference yield:

: 730971-32-1
3-(dihydroxyboranyl)-4-methoxybenzoic acid

: 1217334-47-8
2-(4-fluorophenyl)-5-(5-(isobutylcarbamoyl)-2-isopropoxyphenyl)-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 85 °C / Sealed vial

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

3: boron tribromide-dimethyl sulfide complex / toluene / 30 h / 100 °C / Inert atmosphere; Sealed tube

4: N,N-dimethyl-formamide / 22 - 70 °C

With boron tribromide-dimethyl sulfide complex; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1217340-76-5
2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl trifluoromethanesulfonate

: 1217334-47-8
2-(4-fluorophenyl)-5-(5-(isobutylcarbamoyl)-2-isopropoxyphenyl)-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 85 °C / Sealed vial

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

3: boron tribromide-dimethyl sulfide complex / toluene / 30 h / 100 °C / Inert atmosphere; Sealed tube

4: N,N-dimethyl-formamide / 22 - 70 °C

With boron tribromide-dimethyl sulfide complex; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;