(3Z,6Z)-3-((5-tert-butyl-1H-imidazol-4-yl)methylene)-6-(3-(3-chlorobenzoyl)benzylidene)piperazine-2,5-dione

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Chemical Name:(3Z,6Z)-3-((5-tert-butyl-1H-imidazol-4-yl)methylene)-6-(3-(3-chlorobenzoyl)benzylidene)piperazine-2,5-dione
CAS No.:1314314-59-4
Molecular Formula:C₂₆H₂₃ClN₄O₃
Molecular Weight:474.947
Hs Code.:

Synonyms:(3Z,6Z)-3-((5-tert-butyl-1H-imidazol-4-yl)methylene)-6-(3-(3-chlorobenzoyl)benzylidene)piperazine-2,5-dione

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Chemical Property of (3Z,6Z)-3-((5-tert-butyl-1H-imidazol-4-yl)methylene)-6-(3-(3-chlorobenzoyl)benzylidene)piperazine-2,5-dione

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Technology Process of (3Z,6Z)-3-((5-tert-butyl-1H-imidazol-4-yl)methylene)-6-(3-(3-chlorobenzoyl)benzylidene)piperazine-2,5-dione

There total 5 articles about (3Z,6Z)-3-((5-tert-butyl-1H-imidazol-4-yl)methylene)-6-(3-(3-chlorobenzoyl)benzylidene)piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 714273-84-4
1-acetyl-3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-2,5-piperazinedione

: 1267636-78-1
3-(3-chlorobenzoyl)benzaldehyde

: 1314314-59-4
(3Z,6Z)-3-((5-tert-butyl-1H-imidazol-4-yl)methylene)-6-(3-(3-chlorobenzoyl)benzylidene)piperazine-2,5-dione

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2012.05.059

Reference yield:

: C₁₄H₁₁ClO₂

: 1314314-59-4
(3Z,6Z)-3-((5-tert-butyl-1H-imidazol-4-yl)methylene)-6-(3-(3-chlorobenzoyl)benzylidene)piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: dipyridinium dichromate / dichloromethane / 2 h / 20 °C / Molecular sieve

2: caesium carbonate / N,N-dimethyl-formamide / 70 °C / Inert atmosphere

With dipyridinium dichromate; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.05.059

Reference yield:

: 535-80-8
3-chlorobenzoate

: 1314314-59-4
(3Z,6Z)-3-((5-tert-butyl-1H-imidazol-4-yl)methylene)-6-(3-(3-chlorobenzoyl)benzylidene)piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

2: n-butyllithium / tetrahydrofuran; hexane / Inert atmosphere

3: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2 h / 0 °C / Inert atmosphere

4: dipyridinium dichromate / dichloromethane / 2 h / 20 °C / Molecular sieve

5: caesium carbonate / N,N-dimethyl-formamide / 70 °C / Inert atmosphere

With dipyridinium dichromate; n-butyllithium; diisobutylaluminium hydride; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2012.05.059