N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-morpholino-6-methyl-2-pyrimidinamine

Base Information

Chemical Name:N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-morpholino-6-methyl-2-pyrimidinamine
CAS No.:169882-37-5
Molecular Formula:C₂₀H₂₇BrN₄O
Molecular Weight:419.365
Hs Code.:

Synonyms:N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-morpholino-6-methyl-2-pyrimidinamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-morpholino-6-methyl-2-pyrimidinamine

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Technology Process of N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-morpholino-6-methyl-2-pyrimidinamine

There total 3 articles about N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-morpholino-6-methyl-2-pyrimidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-03-6
ethyl iodide

: 2-N-<2-bromo-4-(1-methylethyl)phenyl>-4-morpholinyl-6-methylpyrimidine

: 169882-37-5
N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-morpholino-6-methyl-2-pyrimidinamine

Guidance literature:: With sodium hydride; Yield given; Multistep reaction; 1.) THF, RT, 20 min, 2.) THF, a) RT, 24 h, b) reflux 5 h;
DOI:10.1021/jm980222w

Reference yield:

: 52026-43-4
4-(2-chloro-6-methylpyrimidin-4-yl)morpholine

: 169882-37-5
N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-morpholino-6-methyl-2-pyrimidinamine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.5 g / ethane-1,2-diol / 1.5 h / Heating

2: 1.) NaH / 1.) THF, RT, 20 min, 2.) THF, a) RT, 24 h, b) reflux 5 h

With sodium hydride; In ethylene glycol;
DOI:10.1021/jm980222w

Reference yield:

: 5424-21-5
2,4-dichloro-6-methylpyrimidine

: 169882-37-5
N-(2-bromo-4-(1-methylethyl)phenyl)-N-ethyl-4-morpholino-6-methyl-2-pyrimidinamine

Guidance literature:: Multi-step reaction with 3 steps

1: 3.8 g / i-Pr₂NEt / ethanol / 1.) 0 deg C, 3 h, 2.) 25 deg C, 24 h, 3.) reflux, 1 h

2: 1.5 g / ethane-1,2-diol / 1.5 h / Heating

3: 1.) NaH / 1.) THF, RT, 20 min, 2.) THF, a) RT, 24 h, b) reflux 5 h

With sodium hydride; N-ethyl-N,N-diisopropylamine; In ethanol; ethylene glycol;
DOI:10.1021/jm980222w