tert-butyl N-({1-[2'-chlorobiphenyl-4-yl-methyl]-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridin-3-yl}carbonyl)glycinate

Base Information

Chemical Name:tert-butyl N-({1-[2'-chlorobiphenyl-4-yl-methyl]-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridin-3-yl}carbonyl)glycinate
CAS No.:1186091-05-3
Molecular Formula:C₂₇H₂₇ClN₂O₆
Molecular Weight:510.974
Hs Code.:

Synonyms:tert-butyl N-({1-[2'-chlorobiphenyl-4-yl-methyl]-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridin-3-yl}carbonyl)glycinate

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Chemical Property of tert-butyl N-({1-[2'-chlorobiphenyl-4-yl-methyl]-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridin-3-yl}carbonyl)glycinate

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Technology Process of tert-butyl N-({1-[2'-chlorobiphenyl-4-yl-methyl]-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridin-3-yl}carbonyl)glycinate

There total 6 articles about tert-butyl N-({1-[2'-chlorobiphenyl-4-yl-methyl]-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridin-3-yl}carbonyl)glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1186091-04-2
tert-butyl 2-(1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetate

: 3900-89-8
2-Chlorobenzeneboronic acid

: 1186091-05-3
tert-butyl N-({1-[2'-chlorobiphenyl-4-yl-methyl]-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridin-3-yl}carbonyl)glycinate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide; at 120 ℃; for 0.75h; microwave irradiation;

Reference yield:

: 1186091-03-1
ethyl 1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridin-3-carboxylate

: 1186091-05-3
tert-butyl N-({1-[2'-chlorobiphenyl-4-yl-methyl]-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridin-3-yl}carbonyl)glycinate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,2-dimethoxyethane / 1.5 h / 120 °C / microwave irradiation

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; N,N-dimethyl-formamide / 0.75 h / 120 °C / microwave irradiation

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 57595-23-0
methyl 4-oxotetrahydrofuran-3-carboxylate

: 1186091-05-3
tert-butyl N-({1-[2'-chlorobiphenyl-4-yl-methyl]-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridin-3-yl}carbonyl)glycinate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / acetic acid / ethanol / 2 h / Reflux

2: pyridine / dmap / dichloromethane / 0 - 20 °C

3: sodium ethanolate / ethanol / 4 h / 85 °C / sealed vial

4: 1,2-dimethoxyethane / 1.5 h / 120 °C / microwave irradiation

5: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; N,N-dimethyl-formamide / 0.75 h / 120 °C / microwave irradiation

With pyridine; sodium ethanolate; sodium carbonate; triethylamine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;