ethyl 1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridin-3-carboxylate

Base Information

Chemical Name:ethyl 1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridin-3-carboxylate
CAS No.:1186091-03-1
Molecular Formula:C₁₇H₁₆BrNO₅
Molecular Weight:394.222
Hs Code.:

Synonyms:ethyl 1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridin-3-carboxylate

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Chemical Property of ethyl 1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridin-3-carboxylate

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Technology Process of ethyl 1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridin-3-carboxylate

There total 4 articles about ethyl 1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridin-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1186091-02-0
methyl-4-[(4-bromobenzyl)(3-ethoxy-3-oxopropanoyl)amino]-2,5-dihydrofuran-3-carboxylate

: 1186091-03-1
ethyl 1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridin-3-carboxylate

Guidance literature:: methyl-4-[(4-bromobenzyl)(3-ethoxy-3-oxopropanoyl)amino]-2,5-dihydrofuran-3-carboxylate; With sodium ethanolate; In ethanol; at 85 ℃; for 4h; sealed vial;

With sodium dihydrogenphosphate; water; In ethyl acetate;

Reference yield:

: 57595-23-0
methyl 4-oxotetrahydrofuran-3-carboxylate

: 1186091-03-1
ethyl 1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridin-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / acetic acid / ethanol / 2 h / Reflux

2: pyridine / dmap / dichloromethane / 0 - 20 °C

3: sodium ethanolate / ethanol / 4 h / 85 °C / sealed vial

With pyridine; sodium ethanolate; triethylamine; dmap; acetic acid; In ethanol; dichloromethane;

Reference yield:

: 3959-07-7
4-Bromobenzylamine

: 1186091-03-1
ethyl 1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridin-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / acetic acid / ethanol / 2 h / Reflux

2: pyridine / dmap / dichloromethane / 0 - 20 °C

3: sodium ethanolate / ethanol / 4 h / 85 °C / sealed vial

With pyridine; sodium ethanolate; triethylamine; dmap; acetic acid; In ethanol; dichloromethane;