tert-butyl 2-(1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetate

Base Information

Chemical Name:tert-butyl 2-(1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetate
CAS No.:1186091-04-2
Molecular Formula:C₂₁H₂₃BrN₂O₆
Molecular Weight:479.327
Hs Code.:

Synonyms:tert-butyl 2-(1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetate

Suppliers and Price of tert-butyl 2-(1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 2-(1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetate

There total 9 articles about tert-butyl 2-(1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1186091-03-1
ethyl 1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridin-3-carboxylate

: 6456-74-2
Glycine tert-butyl ester

: 1186091-04-2
tert-butyl 2-(1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetate

Guidance literature:: In 1,2-dimethoxyethane; at 120 ℃; for 1.5h; microwave irradiation;

Reference yield:

: 57595-23-0
methyl 4-oxotetrahydrofuran-3-carboxylate

: 1186091-04-2
tert-butyl 2-(1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 1.5 h / 90 °C

2: pyridine / dichloromethane / 12 h / 0 - 25 °C / Inert atmosphere

3: sodium hydride / mineral oil; ethanol / 1 h / 25 °C

4: trifluoroacetic acid / 24 h / 70 °C / Inert atmosphere

5: isopropyl alcohol / 16 h / 100 °C

6: potassium carbonate / acetone / 16 h / 20 °C

With pyridine; sodium hydride; potassium carbonate; trifluoroacetic acid; In ethanol; dichloromethane; isopropyl alcohol; acetone; mineral oil;

Reference yield:

: 3959-07-7
4-Bromobenzylamine

: 1186091-04-2
tert-butyl 2-(1-(4-bromobenzyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / acetic acid / ethanol / 2 h / Reflux

2: pyridine / dmap / dichloromethane / 0 - 20 °C

3: sodium ethanolate / ethanol / 4 h / 85 °C / sealed vial

4: 1,2-dimethoxyethane / 1.5 h / 120 °C / microwave irradiation

With pyridine; sodium ethanolate; triethylamine; dmap; acetic acid; In 1,2-dimethoxyethane; ethanol; dichloromethane;