17467-35-5

Basic information

• Product Name: 5-AMINO-3-METHYL-1,2,4-THIADIAZOLE
• Synonyms: TIMTEC-BB SBB005481;3-METHYL-1,2,4-THIADIAZOL-5-YLAMINE;5-AMINO-3-METHYL-1,2,4-THIADIAZOLE;5-Amino-3-Methyl-1,3,4-Thiadiazole;3-methyl-1,2,4-thiadiazol-5-amine;1,2,4-Thiadiazol-5-amine, 3-methyl-;5-Amino-3-methyl-1,2,4-thiadiazole ,99%;5-aMino-3-Methyl-1,2,4-thiadiazole, 98%+
• CAS NO: 17467-35-5
• Molecular Formula: C₃H₅N₃S
• Molecular Weight: 115.16
• Product Categories: Heterocyclic Compounds;Thiadiazol;Amines
• Mol File: 17467-35-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 202 °C
• Boiling Point: 261.2 °C at 760 mmHg
• Flash Point: 111.8 °C
• Appearance: /
• Density: 1.372 g/cm³
• Vapor Pressure: 0.0117mmHg at 25°C
• Refractive Index: 1.63
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.56±0.50(Predicted)
• CAS DataBase Reference: 5-AMINO-3-METHYL-1,2,4-THIADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-3-METHYL-1,2,4-THIADIAZOLE(17467-35-5)
• EPA Substance Registry System: 5-AMINO-3-METHYL-1,2,4-THIADIAZOLE(17467-35-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 17467-35-5(Hazardous Substances Data)

Usage

Chemical Properties

prism

Uses

3-methyl-1,2,4-thiadiazol-5-amine is a useful intermediate used in the preparation of 1,2,4-thiadiazole analogue that functions as a non-peptide inhibitor of beta-secretase.

InChI:InChI=1/C3H5N3S/c1-2-5-3(4)7-6-2/h1H3,(H2,4,5,6)

Upstream product

• 130974-24-2 2-iminopropanenitrile 
• 333-20-0 potassium thioacyanate 
• 20846-52-0 2-chloro-acetamidine 
• 118493-85-9 N-hydroxyacetamidine 
• 67-56-1 methanol 
• 7726-95-6 bromine 
• 124-41-4 sodium methylate 
• 143-37-3 acetamidine 
• 124-42-5 acetamidine hydrochloride 
• 21734-85-0 5-chloro-3-methyl-1,2,4-thiazole 

Downstream Products

• 72212-96-5 N-[3-(4-chloro-phenyl)-[1,2,4]thiadiazol-5-yl]-acetamidine 
• 72212-90-9 5-<(1-Aminoethylidene)amino>-3-chloromethyl-1,2,4-thiadiazole 
• 72212-92-1 N-(3-isopropyl-[1,2,4]thiadiazol-5-yl)-acetamidine 
• 72212-93-2 N-(3-tert-butyl-[1,2,4]thiadiazol-5-yl)-acetamidine 
• 71517-40-3 3-methyl-5,6-dihydro-[1,2,4]thiadiazolo[5,4-c][1,2,4]thiadiazine 7,7-dioxide 
• 112625-31-7 3-methyl-5-(3-phenyl-triazenyl)-[1,2,4]thiadiazole 
• 63682-73-5 3-methyl-6-(4-nitro-phenyl)-imidazo[1,2-d][1,2,4]thiadiazole 
• 95166-42-0 (3-methyl-[1,2,4]thiadiazol-5-yl)-trityl-amine 
• 91909-14-7 N,N'-bis-(3-methyl-[1,2,4]thiadiazol-5-yl)-C-phenyl-methanediamine 
• 91687-95-5 benzylidene-(3-methyl-[1,2,4]thiadiazol-5-yl)-amine 
• 60716-98-5 4-ethyl-3-methyl-4H-[1,2,4]thiadiazol-5-ylideneamine 
• 55723-80-3 N-(3-methyl-[1,2,4]thiadiazol-5-yl)-S-trichloromethyl-thiohydroxylamine 
• 72212-95-4 5-(1-aminoethylideneamino)-3-phenyl-1,2,4-thiadiazole 
• 72212-94-3 N-(3-p-tolyl-[1,2,4]thiadiazol-5-yl)-acetamidine 

Relevant articles and documents

2-mercapto-5-methyl-1,3,4-thiadiazole compound and synthesis method thereof

The invention relates to the technical field of chemical synthesis, particularly to a 2-mercapto-5-methyl-1,3,4-thiadiazole compound and a synthesis method thereof. The synthesis method of the 2-mercapto-5-methyl-1,3,4-thiadiazole compound comprises the following steps: mixing and emulsifying a sulfur-containing compound and a nitrogen-containing compound, and carrying out a cyclization reaction under the action of a catalyst. The synthesis method is simple to operate, the synthesis conditions are easy to realize, the yield is high, and the purity of the prepared 2-mercapto-5-methyl-1,3,4-thiadiazole compound is also high.

NOVEL CEPHALOSPORIN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF

The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R1, and R2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.

Synthesis and evaluation of novel dipeptide-bound 1,2,4-thiadiazoles as irreversible inhibitors of guinea pig liver transglutaminase.

Herein we report the synthesis and evaluation of 14 novel peptides as potential irreversible inactivators of guinea pig liver transglutaminase (TGase). These peptides were designed to resemble Cbz-L-Gln-Gly, known to be a good TGase substrate, and to include a 1,2,4-thiadiazole group. The side chain length of the amino acid residue bearing the inhibitor group was also varied in order to permit investigation of this effect. Their inactivation rate constants were measured using a direct continuous spectrophotometric method and were found to vary between 0.330 to 0.89 microM(-1) min(-1).