(R,E)-2-(4-(benzyloxy)-2-(5-(benzyloxy)pent-3-en-2-yl)-5-methylphenoxy)-N-methoxy-N,2-dimethylpropanamide

Base Information

• Chemical Name: (R,E)-2-(4-(benzyloxy)-2-(5-(benzyloxy)pent-3-en-2-yl)-5-methylphenoxy)-N-methoxy-N,2-dimethylpropanamide
• CAS No.: 1313708-50-7
• Molecular Formula: C₃₂H₃₉NO₅
• Molecular Weight: 517.665
• Mol file: 1313708-50-7.mol

Synonyms:(R,E)-2-(4-(benzyloxy)-2-(5-(benzyloxy)pent-3-en-2-yl)-5-methylphenoxy)-N-methoxy-N,2-dimethylpropanamide

Chemical Property of (R,E)-2-(4-(benzyloxy)-2-(5-(benzyloxy)pent-3-en-2-yl)-5-methylphenoxy)-N-methoxy-N,2-dimethylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,E)-2-(4-(benzyloxy)-2-(5-(benzyloxy)pent-3-en-2-yl)-5-methylphenoxy)-N-methoxy-N,2-dimethylpropanamide

There total 7 articles about (R,E)-2-(4-(benzyloxy)-2-(5-(benzyloxy)pent-3-en-2-yl)-5-methylphenoxy)-N-methoxy-N,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C32H38O5 (1313708-49-4) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → (R,E)-2-(4-(benzyloxy)-2-(5-(benzyloxy)pent-3-en-2-yl)-5-methylphenoxy)-N-methoxy-N,2-dimethylpropanamide (1313708-50-7)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.tet.2011.05.034

Reference yield:

(R,E)-1-(benzyloxy)-4-(1-(benzyloxy)pent-3-en-2-yloxy)-2-methylbenzene (1313708-52-9) → (R,E)-2-(4-(benzyloxy)-2-(5-(benzyloxy)pent-3-en-2-yl)-5-methylphenoxy)-N-methoxy-N,2-dimethylpropanamide (1313708-50-7)

Guidance literature:

Multi-step reaction with 3 steps

1: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / 1,2-dichloro-ethane / 12 h / 100 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 12 h / 107 °C / Inert atmosphere

3: lithium hexamethyldisilazane / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

With tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III); potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; 1: Claisen rearrangement;

DOI:10.1016/j.tet.2011.05.034

Reference yield:

(R,E)-4-(benzyloxy)-2-(5-(benzyloxy)pent-3-en-2-yl)-5-methylphenol (1313708-54-1) → (R,E)-2-(4-(benzyloxy)-2-(5-(benzyloxy)pent-3-en-2-yl)-5-methylphenoxy)-N-methoxy-N,2-dimethylpropanamide (1313708-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 12 h / 107 °C / Inert atmosphere

2: lithium hexamethyldisilazane / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

With potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.tet.2011.05.034

upstream raw materials:

(R,E)-1-(benzyloxy)-4-(1-(benzyloxy)pent-3-en-2-yloxy)-2-methylbenzene

(R,E)-4-(benzyloxy)-2-(5-(benzyloxy)pent-3-en-2-yl)-5-methylphenol

C₃₂H₃₈O₅

N,O-dimethylhydroxylamine*hydrochloride

Downstream raw materials:

(R,E)-4-(4-(benzyloxy)-2-(5-(benzyloxy)pent-3-en-2-yl)-5-methylphenoxy)-4-methylpent-1-en-3-one