(S)-4-trityl-2-hydroxymethylmorpholine

Base Information

Chemical Name:(S)-4-trityl-2-hydroxymethylmorpholine
CAS No.:132073-84-8
Molecular Formula:C₂₄H₂₅NO₂
Molecular Weight:359.468
Hs Code.:

Synonyms:(S)-4-trityl-2-hydroxymethylmorpholine

Suppliers and Price of (S)-4-trityl-2-hydroxymethylmorpholine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-trityl-2-hydroxymethylmorpholine

Chemical Property:

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Technology Process of (S)-4-trityl-2-hydroxymethylmorpholine

There total 4 articles about (S)-4-trityl-2-hydroxymethylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 76-83-5
trityl chloride

: 132073-83-7
(S)-morpholin-2-ylmethanol

: 132073-84-8
(S)-4-trityl-2-hydroxymethylmorpholine

Guidance literature:: With triethylamine; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jm970806i

Reference yield:

: 75239-80-4,123864-74-4
ethanol hydrochloride

: 76-83-5
trityl chloride

: 132073-82-6,943442-96-4
(S)-4-Benzyl-2-(hydroxymethyl)morpholine

: 132073-84-8
(S)-4-trityl-2-hydroxymethylmorpholine

Guidance literature:: With triethylamine; palladium-carbon; In methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol; dichloromethane; di-isopropyl ether; water;

Reference yield:

: 205242-66-6
(2S)-4-(phenylmethyl)-2-{[(phenylmethyl)oxy]methyl}morpholine

: 132073-84-8
(S)-4-trityl-2-hydroxymethylmorpholine

Guidance literature:: Multi-step reaction with 2 steps

1: 22 percent / H₂, conc. aq. HCl / 10percent Pd/C / ethanol / 4 h / 55 - 60 °C / 760 Torr

2: 36 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm970806i