(S)-4-benzyl-2-((benzyloxy)Methyl)Morpholine

Base Information

• Chemical Name: (S)-4-benzyl-2-((benzyloxy)Methyl)Morpholine
• CAS No.: 205242-66-6
• Molecular Formula: C19H23NO2
• Molecular Weight: 297.397
• Mol file: 205242-66-6.mol

Synonyms:(S)-4-benzyl-2-((benzyloxy)Methyl)Morpholine;(2S)- 2-[(Phenylmethoxy)methyl]-4-(phenylmethyl)morpholine;(S)-2-[(Phenylmethoxy)methyl]-4-(phenylmethyl)morpholine;(S)-4-benzyl-2-((benzyloxy)methyl)morpholine hydrochloride

Chemical Property of (S)-4-benzyl-2-((benzyloxy)Methyl)Morpholine

Chemical Property:

• Boiling Point: 415.3±35.0 °C(Predicted)
• PKA: 6.26±0.10(Predicted)
• PSA: 21.70000
• Density: 1.095
• LogP: 3.04210

Purity/Quality:

NLT 98% ^*data from raw suppliers

(S)-4-Benzyl-2-((benzyloxy)methyl)morpholine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-4-benzyl-2-((benzyloxy)Methyl)Morpholine

There total 5 articles about (S)-4-benzyl-2-((benzyloxy)Methyl)Morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(S)-4-Benzyl-6-benzyloxymethyl-morpholin-3-one (205242-65-5) → (2S)-4-(phenylmethyl)-2-{[(phenylmethyl)oxy]methyl}morpholine (205242-66-6)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 0.666667h; Ambient temperature;

DOI:10.1021/jm970806i

Reference yield: 65.0%

2-(benzylamino)ethyl hydrogen sulfate (2133-07-5) + (S)-benzyl glycidyl ether (2930-05-4,14618-80-5,89616-40-0,16495-13-9) → (2S)-4-(phenylmethyl)-2-{[(phenylmethyl)oxy]methyl}morpholine (205242-66-6)

Guidance literature:

2-(benzylamino)ethyl hydrogen sulfate; (S)-benzyl glycidyl ether; With sodium hydroxide; In methanol; water; at 0 - 40 ℃; for 3.33333h;

In methanol; water; toluene; at 0 - 65 ℃; for 3.16667h;

Reference yield:

(R)-benzyl glycidol (14618-80-5) → (2S)-4-(phenylmethyl)-2-{[(phenylmethyl)oxy]methyl}morpholine (205242-66-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / 65 h / Ambient temperature

2: Na, MeOH / 4 h / Heating

3: 98 percent / LAH / diethyl ether / 0.67 h / Ambient temperature

With methanol; lithium aluminium tetrahydride; sodium; In diethyl ether;

DOI:10.1021/jm970806i

upstream raw materials:

(S)-4-Benzyl-6-benzyloxymethyl-morpholin-3-one

(R)-benzyl glycidol

benzylamine

(2S)-1(benzylamino)-3-(benzyloxy)propan-2-ol

Downstream raw materials:

(S)-morpholin-2-ylmethanol

tert-butyl (2S)-2-(bromomethyl)-4-morpholinecarboxylate

Toluene-4-sulfonic acid (S)-4-trityl-morpholin-2-ylmethyl ester

(S)-4-trityl-2-hydroxymethylmorpholine