4-[3-(3-benzoyl-8-trifluoromethyl-quinolin-4-yl)-phenoxymethyl]-benzoic acid methyl ester

Base Information

Chemical Name:4-[3-(3-benzoyl-8-trifluoromethyl-quinolin-4-yl)-phenoxymethyl]-benzoic acid methyl ester
CAS No.:912553-39-0
Molecular Formula:C₃₂H₂₂F₃NO₄
Molecular Weight:541.526
Hs Code.:

Synonyms:4-[3-(3-benzoyl-8-trifluoromethyl-quinolin-4-yl)-phenoxymethyl]-benzoic acid methyl ester

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Chemical Property of 4-[3-(3-benzoyl-8-trifluoromethyl-quinolin-4-yl)-phenoxymethyl]-benzoic acid methyl ester

Chemical Property:

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Technology Process of 4-[3-(3-benzoyl-8-trifluoromethyl-quinolin-4-yl)-phenoxymethyl]-benzoic acid methyl ester

There total 6 articles about 4-[3-(3-benzoyl-8-trifluoromethyl-quinolin-4-yl)-phenoxymethyl]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 854765-81-4
[4-(3-hydroxyphenyl)-8-(trifluoromethyl)quinolin-3-yl](phenyl)methanone

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 912553-39-0
4-[3-(3-benzoyl-8-trifluoromethyl-quinolin-4-yl)-phenoxymethyl]-benzoic acid methyl ester

Guidance literature:: With potassium carbonate; In acetone; for 2h; Heating;
DOI:10.1021/jm0609566

Reference yield:

: 854777-98-3
(4-hydroxy-8-trifluoromethyl-quinolin-3-yl)phenylmethanone

: 912553-39-0
4-[3-(3-benzoyl-8-trifluoromethyl-quinolin-4-yl)-phenoxymethyl]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / K₂CO₃ / dimethylformamide / 1 h / 20 °C

2: 85 percent / K₃PO₄ / Pd(PPh₃)4 / dioxane / 20 h / Heating

3: 87 percent / K₂CO₃ / acetone / 2 h / Heating

With potassium phosphate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; N,N-dimethyl-formamide; acetone; 2: Suzuki coupling;
DOI:10.1021/jm0609566

Reference yield:

: 854777-97-2
2-benzoyl-3-(2-trifluoromethylphenylamino)acrylic acid ethyl ester

: 912553-39-0
4-[3-(3-benzoyl-8-trifluoromethyl-quinolin-4-yl)-phenoxymethyl]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 56 percent / various solvent(s); diethyl ether / 4 h / Heating

2: 65 percent / K₂CO₃ / dimethylformamide / 1 h / 20 °C

3: 85 percent / K₃PO₄ / Pd(PPh₃)4 / dioxane / 20 h / Heating

4: 87 percent / K₂CO₃ / acetone / 2 h / Heating

With potassium phosphate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide; acetone; 3: Suzuki coupling;
DOI:10.1021/jm0609566