4'-{[1-(5-ethoxypyrimidin-2-yl)-4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-carbonitrile

Base Information

Chemical Name:4'-{[1-(5-ethoxypyrimidin-2-yl)-4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-carbonitrile
CAS No.:1312938-94-5
Molecular Formula:C₂₆H₂₂N₄O₃
Molecular Weight:438.486
Hs Code.:

Synonyms:4'-{[1-(5-ethoxypyrimidin-2-yl)-4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-carbonitrile

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Chemical Property of 4'-{[1-(5-ethoxypyrimidin-2-yl)-4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-carbonitrile

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Technology Process of 4'-{[1-(5-ethoxypyrimidin-2-yl)-4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-carbonitrile

There total 1 articles about 4'-{[1-(5-ethoxypyrimidin-2-yl)-4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1312938-93-4
1-(5-ethoxypyrimidin-2-yl)-4-hydroxy-6-methylpyridin-2(1H)-one

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 1312938-94-5
4'-{[1-(5-ethoxypyrimidin-2-yl)-4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-carbonitrile

Guidance literature:: With lithium chloride; In N,N-dimethyl-formamide; at 70 ℃;

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 1312938-94-5
4'-{[1-(5-ethoxypyrimidin-2-yl)-4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-carbonitrile

: 1312939-08-4
C₂₇H₂₁F₃N₄O₅S

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1312938-94-5
4'-{[1-(5-ethoxypyrimidin-2-yl)-4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-carbonitrile

: 1312938-69-4
3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methylpyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 2 h / 20 °C

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride / toluene; tetrahydrofuran / 1.5 h / 0 - 90 °C / Inert atmosphere

3: di(n-butyl)tin oxide; trimethylsilylazide / toluene / 16 h / Reflux; Inert atmosphere

With pyridine; trimethylsilylazide; di(n-butyl)tin oxide; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In tetrahydrofuran; dichloromethane; toluene;