[2-(2-Methoxy-pyrrolidin-1-yl)-2-oxo-ethyl]-carbamic acid benzyl ester

Base Information

• Chemical Name: [2-(2-Methoxy-pyrrolidin-1-yl)-2-oxo-ethyl]-carbamic acid benzyl ester
• CAS No.: 69352-22-3
• Molecular Formula: C₁₅H₂₀N₂O₄
• Molecular Weight: 292.335
• Mol file: 69352-22-3.mol

Synonyms:[2-(2-Methoxy-pyrrolidin-1-yl)-2-oxo-ethyl]-carbamic acid benzyl ester

Chemical Property of [2-(2-Methoxy-pyrrolidin-1-yl)-2-oxo-ethyl]-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of [2-(2-Methoxy-pyrrolidin-1-yl)-2-oxo-ethyl]-carbamic acid benzyl ester

There total 2 articles about [2-(2-Methoxy-pyrrolidin-1-yl)-2-oxo-ethyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

methanol (67-56-1) + (2S)-1-(2-[[(benzyloxy)carbonyl]amino]acetyl)tetrahydro-1H-pyrrole-2-carboxylic acid (1160-54-9) → [2-(2-Methoxy-pyrrolidin-1-yl)-2-oxo-ethyl]-carbamic acid benzyl ester (69352-22-3)

Guidance literature:

With tris(2,2'-bipyridyl)ruthenium dichloride; 1-acetoxy-1,2-benziodoxol-3-one; In acetonitrile; at 20 ℃; for 15h; Reagent/catalyst; Solvent; Catalytic behavior; Irradiation;

DOI:10.1039/d0sc06180h

Reference yield:

→ [2-(2-Methoxy-pyrrolidin-1-yl)-2-oxo-ethyl]-carbamic acid benzyl ester (69352-22-3)

Guidance literature:

Z-Gly-prolin, NaOCH3, in Me., anodische Oxid.;

DOI:10.1021/jo01323a038

Reference yield: 72.0%

[2-(2-Methoxy-pyrrolidin-1-yl)-2-oxo-ethyl]-carbamic acid benzyl ester (69352-22-3) + 5-fluoro-2,4-bis(trimethylsilyloxy)pyrimidine (17242-85-2) → {2-[2-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidin-1-yl]-2-oxo-ethyl}-carbamic acid benzyl ester (73269-79-1)

Guidance literature:

With tin(IV) chloride; In dichloromethane; acetonitrile; at -15 - -13 ℃; for 3h;

DOI:10.1021/jo00348a020

upstream raw materials:

methanol

(2S)-1-(2-[[(benzyloxy)carbonyl]amino]acetyl)tetrahydro-1H-pyrrole-2-carboxylic acid

Downstream raw materials:

{2-[2-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidin-1-yl]-2-oxo-ethyl}-carbamic acid benzyl ester