diazomethyl hexahydrobenzyl ketone

Base Information

• Chemical Name: diazomethyl hexahydrobenzyl ketone
• CAS No.: 27473-43-4
• Molecular Formula: C₉H₁₄N₂O
• Molecular Weight: 166.223
• Mol file: 27473-43-4.mol

Synonyms:diazomethyl hexahydrobenzyl ketone

Chemical Property of diazomethyl hexahydrobenzyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diazomethyl hexahydrobenzyl ketone

There total 3 articles about diazomethyl hexahydrobenzyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + cyclohexylacetic acid chloride (23860-35-7) → diazomethyl hexahydrobenzyl ketone (27473-43-4)

Guidance literature:

In diethyl ether; for 2h;

DOI:10.1021/jo00138a008

Reference yield:

N-methyl-N-nitrosotoluene-p-sulfonamide (80-11-5) + cyclohexylacetic acid chloride (23860-35-7) → diazomethyl hexahydrobenzyl ketone (27473-43-4)

Guidance literature:

With ethoxyethoxyethanol; potassium hydroxide; In diethyl ether; water; at 0 ℃; for 3h;

DOI:10.1021/jacs.0c09504

Reference yield:

→ diazomethyl hexahydrobenzyl ketone (27473-43-4)

Guidance literature:

aus Cyclohexylacetylchlorid u. Diazomethan;

upstream raw materials:

diazomethane

cyclohexylacetic acid chloride

N-methyl-N-nitrosotoluene-p-sulfonamide

Downstream raw materials:

4-Ethoxy-benzenesulfonic acid 3-cyclohexyl-2-oxo-propyl ester

spiro<3,5>nonan-2-one

cis-hexahydro-1H-inden-2(3H)-one

1,3-Dicyclohexylacetone

Refernces

• 1、 Kim, Kyoung Soon,Kimball, S. David,Misra, Raj N.,Rawlins, David B.,Hunt, John T.,Xiao, Hai-Yun,Lu, Songfeng,Qian, Ligang,Han, Wen-Ching,Shan, Weifang,Mitt, Toomas,Cai, Zhen-Wei,Poss, Michael A.,Zhu, Hong,Sack, John S.,Tokarski, John S.,Chang, Chieh Ying,Pavletich, Nikola,Kamath, Amrita,Humphreys, William G.,Marathe, Punit,Bursuker, Isia,Kellar, Kristen A.,Roongta, Urvashi,Batorsky, Roberta,Mulheron, Janet G.,Bol, David,Fairchild, Craig R.,Lee, Francis Y.,Webster, Kevin R.. "Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: Synthesis, x-ray crystallographic analysis, and biological activities". . p. 3905 - 3927. Retrieved 2007/10/03.
• 2、 Wenkert, Ernest,Davis, Linda L.,Mylari, Banavara L.,Solomon, Mary F.,Silva, Roberto R. da,et al.. "Cyclopentanone Synthesis by Intramolecular Carbon-Hydrogen Insertion of Diazo Ketones. A Diterpene-to-Steroid Skeleton Conversion". . p. 3242 - 3247. Retrieved 2007/10/02.