Technology Process of 1,4-dibenzyl-3-(2'-thiopyridyl)-6-(2-valerolactonyl)-2,5-piperazinedione (syn, minor diastereomer)
There total 4 articles about 1,4-dibenzyl-3-(2'-thiopyridyl)-6-(2-valerolactonyl)-2,5-piperazinedione (syn, minor diastereomer) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 98 percent / N-bromosuccinimide / benzoyl peroxide / CCl4 / 2 h / Heating
2: 1.) NaH / 1.) THF, room temp., 30 min; 2.) THF, 30 min
3: silver triflate / tetrahydrofuran / 2 h / Ambient temperature
With
N-Bromosuccinimide; silver trifluoromethanesulfonate; sodium hydride;
dibenzoyl peroxide;
In
tetrahydrofuran; tetrachloromethane;
DOI:10.1021/ja00297a034
- Guidance literature:
-
Multi-step reaction with 4 steps
1: NaH / dimethylformamide / 25 °C
2: 98 percent / N-bromosuccinimide / benzoyl peroxide / CCl4 / 2 h / Heating
3: 1.) NaH / 1.) THF, room temp., 30 min; 2.) THF, 30 min
4: silver triflate / tetrahydrofuran / 2 h / Ambient temperature
With
N-Bromosuccinimide; silver trifluoromethanesulfonate; sodium hydride;
dibenzoyl peroxide;
In
tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00297a034
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) NaH / 1.) THF, room temp., 30 min; 2.) THF, 30 min
2: silver triflate / tetrahydrofuran / 2 h / Ambient temperature
With
silver trifluoromethanesulfonate; sodium hydride;
In
tetrahydrofuran;
DOI:10.1021/ja00297a034
