4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-N-[(dimethylamino)sulfonyl]difluorobenzamide

Base Information

Chemical Name:4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-N-[(dimethylamino)sulfonyl]difluorobenzamide
CAS No.:1443430-81-6
Molecular Formula:C₁₈H₂₀ClF₂N₃O₅S
Molecular Weight:463.89
Hs Code.:

Synonyms:4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-N-[(dimethylamino)sulfonyl]difluorobenzamide

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Chemical Property of 4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-N-[(dimethylamino)sulfonyl]difluorobenzamide

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Technology Process of 4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-N-[(dimethylamino)sulfonyl]difluorobenzamide

There total 6 articles about 4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-N-[(dimethylamino)sulfonyl]difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1355066-41-9
5-chloro-6-(1-propan-2-yloxy)-3-pyridinol

: 1443430-87-2
4-(bromomethyl)-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide

: 1443430-81-6
4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-N-[(dimethylamino)sulfonyl]difluorobenzamide

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 16h;

Reference yield:

: 1443432-56-1
N-[(dimethylamino)sulfonyl]-2,5-difluoro-4-methylbenzamide

: 1443430-81-6
4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-N-[(dimethylamino)sulfonyl]difluorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / 1,2-dichloro-ethane / Reflux; Irradiation

2: potassium carbonate / dimethyl sulfoxide / 16 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In dimethyl sulfoxide; 1,2-dichloro-ethane;

Reference yield:

: 103877-80-1
2,5-difluoro-4-methyl-benzoic acid

: 1443430-81-6
4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-N-[(dimethylamino)sulfonyl]difluorobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 0.33 h / 20 °C

1.2: 3 h / 60 °C / Inert atmosphere

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / 1,2-dichloro-ethane / Reflux; Irradiation

3.1: potassium carbonate / dimethyl sulfoxide / 16 h / 20 °C

With dmap; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; 1,2-dichloro-ethane;