5-chloro-6-(1-propan-2-yloxy)-3-pyridinol

Base Information

• Chemical Name: 5-chloro-6-(1-propan-2-yloxy)-3-pyridinol
• CAS No.: 1355066-41-9
• Molecular Formula: C₈H₁₀ClNO₂
• Molecular Weight: 187.626
• Mol file: 1355066-41-9.mol

Synonyms:5-chloro-6-(1-propan-2-yloxy)-3-pyridinol

Chemical Property of 5-chloro-6-(1-propan-2-yloxy)-3-pyridinol

Chemical Property:

Purity/Quality:

5-Chloro-6-isopropoxypyridin-3-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-6-(1-propan-2-yloxy)-3-pyridinol

There total 4 articles about 5-chloro-6-(1-propan-2-yloxy)-3-pyridinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-2-isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1344997-94-9) → 5-chloro-6-(1-propan-2-yloxy)-3-pyridinol (1355066-41-9)

Guidance literature:

With peracetic acid; In water; acetic acid; at 0 - 20 ℃; for 4h;

Reference yield:

2,3-dichloro-pyridine (2402-77-9) → 5-chloro-6-(1-propan-2-yloxy)-3-pyridinol (1355066-41-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 5 - 20 °C

1.2: 18 h / Reflux

2.1: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / n-heptane / 18 h / 20 °C

3.1: peracetic acid; acetic acid / 4 h / 5 - 20 °C

With peracetic acid; sodium hydride; acetic acid; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; n-heptane;

Reference yield:

2-Isopropoxy-3-chloropyridine (282723-22-2) → 5-chloro-6-(1-propan-2-yloxy)-3-pyridinol (1355066-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / n-heptane / 18 h / 20 °C

2: peracetic acid; acetic acid / 4 h / 5 - 20 °C

With peracetic acid; acetic acid; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In n-heptane;

upstream raw materials:

2,3-dichloro-pyridine

3-chloro-2-isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

2-Isopropoxy-3-chloropyridine

5-bromo-3-chloro-2-isopropoxypyridine

Downstream raw materials:

4-[(5-Chloro-6-isopropoxypyridin-3-yl)oxy]-2,5-difluoro-N-(methylsulfonyl)benzamide

4-Methylphenyl 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-2,5-difluorobenzoate

6-isopropoxypyridin-3-ol

3-bromo-4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]benzonitrile