ethyl 2-nitro-6-<2-(N-benzy;-N-propylaminoethyl)phenyl>pyruvate

Base Information

• Chemical Name: ethyl 2-nitro-6-<2-(N-benzy;-N-propylaminoethyl)phenyl>pyruvate
• CAS No.: 173990-72-2
• Molecular Formula: C₂₃H₂₈N₂O₅
• Molecular Weight: 412.486
• Mol file: 173990-72-2.mol

Synonyms:ethyl 2-nitro-6-<2-(N-benzy;-N-propylaminoethyl)phenyl>pyruvate

Chemical Property of ethyl 2-nitro-6-<2-(N-benzy;-N-propylaminoethyl)phenyl>pyruvate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-nitro-6-<2-(N-benzy;-N-propylaminoethyl)phenyl>pyruvate

There total 4 articles about ethyl 2-nitro-6-<2-(N-benzy;-N-propylaminoethyl)phenyl>pyruvate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

oxalic acid diethyl ester (95-92-1) + N-benzyl-N-propyl-2-(2-methyl-3-nitrophenyl)ethylamine (763060-96-4) → ethyl 2-nitro-6-<2-(N-benzy;-N-propylaminoethyl)phenyl>pyruvate (173990-72-2)

Guidance literature:

With potassium ethoxide; In diethyl ether;

DOI:10.1016/0223-5234(96)88317-6

Reference yield:

2-(3-nitro-2-methylphenyl)acetic acid (23876-15-5) → ethyl 2-nitro-6-<2-(N-benzy;-N-propylaminoethyl)phenyl>pyruvate (173990-72-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / SOCl₂ / 3 h / Heating

2: 1.) SOCl₂, 2.) Na₂CO₃ / 1.) reflux, 3 h, 2.) H₂O, toluene, RT, 2 h

3: 1.) B₂H₆, 2.) 6N HCl / 1.) THF, a) reflux, 12 h, b) RT, 12 h, 2.) reflux, 1 h

4: 48 percent / EtOK / diethyl ether

With hydrogenchloride; thionyl chloride; potassium ethoxide; sodium carbonate; diborane; In diethyl ether;

DOI:10.1016/0223-5234(96)88317-6

Reference yield:

2-methyl-3-nitrophenylethanoyl chloride (101566-00-1) → ethyl 2-nitro-6-<2-(N-benzy;-N-propylaminoethyl)phenyl>pyruvate (173990-72-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) SOCl₂, 2.) Na₂CO₃ / 1.) reflux, 3 h, 2.) H₂O, toluene, RT, 2 h

2: 1.) B₂H₆, 2.) 6N HCl / 1.) THF, a) reflux, 12 h, b) RT, 12 h, 2.) reflux, 1 h

3: 48 percent / EtOK / diethyl ether

With hydrogenchloride; thionyl chloride; potassium ethoxide; sodium carbonate; diborane; In diethyl ether;

DOI:10.1016/0223-5234(96)88317-6

upstream raw materials:

oxalic acid diethyl ester

N-benzyl-N-propyl-2-(2-methyl-3-nitrophenyl)ethylamine

2-(3-nitro-2-methylphenyl)acetic acid

2-methyl-3-nitrophenylethanoyl chloride

Downstream raw materials:

2-nitro-6-<2-(N-benzyl-N-propylamino)ethyl>phenylacetic acid

4-<2-(N-benzyl-N-propylamino)ethyl>-2-indolone

2-nitro-6-<2-(N-benzyl-N-propylaminoethyl)>phenylpyruvic acid