(Sp)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidylyl-(3'->5')-3'-O-[(1,1-dimethylethyl)diphenylsilyl]-2'-deoxythymidine 3'-methylphosphonate

Base Information

Chemical Name:(Sp)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidylyl-(3'->5')-3'-O-[(1,1-dimethylethyl)diphenylsilyl]-2'-deoxythymidine 3'-methylphosphonate
CAS No.:195307-35-8
Molecular Formula:C₅₈H₆₅N₄O₁₃PSi
Molecular Weight:1085.23
Hs Code.:

Synonyms:(Sp)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidylyl-(3'->5')-3'-O-[(1,1-dimethylethyl)diphenylsilyl]-2'-deoxythymidine 3'-methylphosphonate

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Chemical Property of (Sp)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidylyl-(3'->5')-3'-O-[(1,1-dimethylethyl)diphenylsilyl]-2'-deoxythymidine 3'-methylphosphonate

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Technology Process of (Sp)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidylyl-(3'->5')-3'-O-[(1,1-dimethylethyl)diphenylsilyl]-2'-deoxythymidine 3'-methylphosphonate

There total 5 articles about (Sp)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidylyl-(3'->5')-3'-O-[(1,1-dimethylethyl)diphenylsilyl]-2'-deoxythymidine 3'-methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114079-04-8,129446-26-0,129446-28-2
5'-dimethoxytritylthymidine-3'-diisopropylaminomethylphosphonoamidite

: 195307-35-8
(Sp)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidylyl-(3'->5')-3'-O-[(1,1-dimethylethyl)diphenylsilyl]-2'-deoxythymidine 3'-methylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 2-(triphenylmethyl)-4,5-dicyanoimidazole / CH₂Cl₂ / 20 °C

2: TBHP

With tert.-butylhydroperoxide; 2-(triphenylmethyl)-4,5-dicyanoimidazole; In dichloromethane; 1: Substitution / 2: Oxidation;
DOI:10.1080/07328319908044654

Reference yield:

: 83467-48-5
1-[(2R,4S,5R)-4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 195307-35-8
(Sp)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidylyl-(3'->5')-3'-O-[(1,1-dimethylethyl)diphenylsilyl]-2'-deoxythymidine 3'-methylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 2-(triphenylmethyl)-4,5-dicyanoimidazole / CH₂Cl₂ / 20 °C

2: TBHP

With tert.-butylhydroperoxide; 2-(triphenylmethyl)-4,5-dicyanoimidazole; In dichloromethane; 1: Substitution / 2: Oxidation;
DOI:10.1080/07328319908044654

Reference yield:

: 114079-04-8,129446-26-0,129446-28-2
5'-dimethoxytritylthymidine-3'-diisopropylaminomethylphosphonoamidite

: 83467-48-5
1-[(2R,4S,5R)-4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 195307-35-8
(Sp)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidylyl-(3'->5')-3'-O-[(1,1-dimethylethyl)diphenylsilyl]-2'-deoxythymidine 3'-methylphosphonate

: (Rp)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidylyl-(3'->5')-3'-O-[(1,1-dimethylethyl)diphenylsilyl]-2'-deoxythymidine 3'-methylphosphonate

Guidance literature:: With 5-<(1R,2R)-2-(2-methoxy)bornyl>tetrazole; In dichloromethane; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; further reagents;
DOI:10.1080/07328319708002948