4-[5-(4-phenoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid methyl ester

Base Information

Chemical Name:4-[5-(4-phenoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid methyl ester
CAS No.:791613-73-5
Molecular Formula:C₂₂H₁₆N₂O₄
Molecular Weight:372.38
Hs Code.:

Synonyms:4-[5-(4-phenoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid methyl ester

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Chemical Property of 4-[5-(4-phenoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid methyl ester

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Technology Process of 4-[5-(4-phenoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid methyl ester

There total 2 articles about 4-[5-(4-phenoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1623-95-6
4-phenoxybenzoyl chloride

: 184778-33-4,65695-05-8
4-(N-hydroxycarbamimidoyl)-benzoic acid methyl ester

: 791613-73-5
4-[5-(4-phenoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid methyl ester

Guidance literature:: 4-phenoxybenzoyl chloride; 4-(N-hydroxycarbamimidoyl)-benzoic acid methyl ester; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 12h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 48h;
DOI:10.1016/j.bmcl.2004.07.077

Reference yield:

: 1129-35-7
4-cyanobenzoic acid methyl ester

: 791613-73-5
4-[5-(4-phenoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: H₂NOH; MeONa / methanol / 48 h / 20 °C

2.1: DIPEA / CH₂Cl₂ / 12 h / 0 - 20 °C

2.2: TBAF / tetrahydrofuran / 48 h / 20 °C

With hydroxylamine; sodium methylate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2004.07.077