diethyl N-[(4S)-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoylamino]-4-methoxycarbonylbutyl]-L-glutamate

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Chemical Name:diethyl N-[(4S)-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoylamino]-4-methoxycarbonylbutyl]-L-glutamate
CAS No.:162007-18-3
Molecular Formula:C₃₀H₄₁N₇O₇
Molecular Weight:611.698
Hs Code.:

Synonyms:diethyl N-[(4S)-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoylamino]-4-methoxycarbonylbutyl]-L-glutamate

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Chemical Property of diethyl N-[(4S)-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoylamino]-4-methoxycarbonylbutyl]-L-glutamate

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Technology Process of diethyl N-[(4S)-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoylamino]-4-methoxycarbonylbutyl]-L-glutamate

There total 8 articles about diethyl N-[(4S)-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoylamino]-4-methoxycarbonylbutyl]-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 149010-53-7
4-<2-(2,4-Diaminopyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoic acid

: (S)-2-((S)-4-Amino-4-methoxycarbonyl-butylamino)-pentanedioic acid diethyl ester; hydrochloride

: 162007-18-3
diethyl N-[(4S)-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoylamino]-4-methoxycarbonylbutyl]-L-glutamate

Guidance literature:: With triethylamine; diethyl dicarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1248/cpb.48.1270

Reference yield:

: 16450-41-2
L-glutamic acid diethyl ester

: 162007-18-3
diethyl N-[(4S)-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoylamino]-4-methoxycarbonylbutyl]-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / 16 h / 60 °C

2: HCl / ethyl acetate / 2 h

3: DEPC; Et₃N / dimethylformamide / 2 h / 20 °C

With hydrogenchloride; triethylamine; diethyl dicarbonate; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.48.1270

Reference yield:

: 72086-72-7
N-tert-butoxycarbonylglutamic acid methyl ester

: 162007-18-3
diethyl N-[(4S)-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoylamino]-4-methoxycarbonylbutyl]-L-glutamate

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / tetrahydrofuran / 0.5 h

2: NaBH₄ / H₂O; tetrahydrofuran

3: Et₃N / CH₂Cl₂ / 0.5 h

4: NaI / acetone / 16 h / 20 °C

5: 63 percent / 16 h / 60 °C

6: HCl / ethyl acetate / 2 h

7: DEPC; Et₃N / dimethylformamide / 2 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; triethylamine; diethyl dicarbonate; sodium iodide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.48.1270