2-[(5-chloro-2-methyl-3-piperazin-1-ylphenyl)oxy]-N,N-dimethylethanamine

Base Information

Chemical Name:2-[(5-chloro-2-methyl-3-piperazin-1-ylphenyl)oxy]-N,N-dimethylethanamine
CAS No.:871464-75-4
Molecular Formula:C₁₅H₂₄ClN₃O
Molecular Weight:297.828
Hs Code.:

Synonyms:2-[(5-chloro-2-methyl-3-piperazin-1-ylphenyl)oxy]-N,N-dimethylethanamine

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Chemical Property of 2-[(5-chloro-2-methyl-3-piperazin-1-ylphenyl)oxy]-N,N-dimethylethanamine

Chemical Property:

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Technology Process of 2-[(5-chloro-2-methyl-3-piperazin-1-ylphenyl)oxy]-N,N-dimethylethanamine

There total 7 articles about 2-[(5-chloro-2-methyl-3-piperazin-1-ylphenyl)oxy]-N,N-dimethylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871339-41-2
1,1-dimethylethyl 4-(5-chloro-3-{[2-(dimethylamino)ethyl]oxy}-2-methylphenyl)piperazine-1-carboxylate

: 871464-75-4
2-[(5-chloro-2-methyl-3-piperazin-1-ylphenyl)oxy]-N,N-dimethylethanamine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; for 0.0333333h; Reflux;
DOI:10.1016/j.bmcl.2012.01.105

Reference yield:

: 870606-29-4
5-chloro-3-iodo-2-methylaniline

: 871464-75-4
2-[(5-chloro-2-methyl-3-piperazin-1-ylphenyl)oxy]-N,N-dimethylethanamine

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / diethylene glycol dimethyl ether / 24 h / Reflux

2: tetrahydrofuran / 15 h / 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 24 h / 80 °C

4: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran / 0.5 h / 20 °C

5: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

6: hydrogenchloride / 1,4-dioxane; methanol / 0.03 h / Reflux

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dihydrogen peroxide; potassium acetate; potassium carbonate; caesium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; diethylene glycol dimethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.01.105

Reference yield:

: 871339-21-8
1-(5-chloro-3-iodo-2-methylphenyl)piperazine

: 871464-75-4
2-[(5-chloro-2-methyl-3-piperazin-1-ylphenyl)oxy]-N,N-dimethylethanamine

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 15 h / 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 24 h / 80 °C

3: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran / 0.5 h / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

5: hydrogenchloride / 1,4-dioxane; methanol / 0.03 h / Reflux

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dihydrogen peroxide; potassium acetate; caesium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.01.105