3-ForMyl Tyrosol α-Acetate

Base Information

• Chemical Name: 3-ForMyl Tyrosol α-Acetate
• CAS No.: 150994-00-6
• Molecular Formula: C₁₁H₁₂O₄
• Molecular Weight: 208.214
• Mol file: 150994-00-6.mol

Synonyms:2-(3-formyl-4-hydroxyphenyl)ethyl acetate

Chemical Property of 3-ForMyl Tyrosol α-Acetate

Chemical Property:

• Boiling Point: 323.7±32.0 °C(Predicted)
• PKA: 8.15±0.20(Predicted)
• Density: 1.233±0.06 g/cm3(Predicted)

Purity/Quality:

3-FormylTyrosolα-Acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Intermediate in the preparation of Hydroxy Tyrosol (H977000).

Technology Process of 3-ForMyl Tyrosol α-Acetate

There total 3 articles about 3-ForMyl Tyrosol α-Acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-(4-hydroxyphenyl)ethyl acetate (58556-55-1) → 2-(3-formyl-4-hydroxyphenyl)ethyl acetate (150994-00-6)

Guidance literature:

With triethylamine; magnesium chloride; at 80 ℃;

DOI:10.1016/j.tetlet.2011.07.063

Reference yield:

p-hydroxyphenethyl alcohol (501-94-0) → 2-(3-formyl-4-hydroxyphenyl)ethyl acetate (150994-00-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / CH₂Cl₂ / Ambient temperature; overnight

2: 1) SnCl₄, triethylamine / 1) toluene, CH₂Cl₂, 20 min, room temperature 2) 100 deg C, 8 h

With tin(IV) chloride; triethylamine; In dichloromethane;

DOI:10.1246/bcsj.63.2672

Reference yield:

2-(4-hydroxyphenyl)ethyl acetate (58556-55-1) → 2-(3-formyl-4-hydroxyphenyl)ethyl acetate (150994-00-6)

Guidance literature:

With tin(IV) chloride; triethylamine; Yield given. Multistep reaction; 1) toluene, CH₂Cl₂, 20 min, room temperature 2) 100 deg C, 8 h;

DOI:10.1246/bcsj.63.2672

upstream raw materials:

2-(4-hydroxyphenyl)ethyl acetate

p-hydroxyphenethyl alcohol

formaldehyd

Downstream raw materials:

4-(benzyloxy)-3-formyl phenethyl acetate

C₁₈H₁₈O₅

C₁₁H₁₂O₅

C₁₇H₁₈O₄