1-BOC-4-CYANOMETHYL PIPERAZINE

Base Information

• Chemical Name: 1-BOC-4-CYANOMETHYL PIPERAZINE
• CAS No.: 77290-31-4
• Molecular Formula: C₁₁H₁₉N₃O₂
• Molecular Weight: 225.291
• Hs Code.: 2933599090
• Mol file: 77290-31-4.mol

Synonyms:1-(tert-Butoxycarbonyl)-4-cyanomethylpiperazine;4-(Cyanomethyl)piperazine-1-carboxylic acid tert-butyl ester; tert-Butyl4-cyanomethylpiperazine-1-carboxylate

Chemical Property of 1-BOC-4-CYANOMETHYL PIPERAZINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.489
• Boiling Point: 327.887°C at 760 mmHg
• Flash Point: 152.101°C
• PSA: 56.57000
• Density: 1.09g/cm³
• LogP: 0.93848
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-4-cyanomethylPiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-4-CYANOMETHYL PIPERAZINE

There total 4 articles about 1-BOC-4-CYANOMETHYL PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-t-Butoxycarbonylpiperazine (57260-71-6) + cyanomethyl bromide (590-17-0) → tert-butyl 4-(cyanomethyl)piperazine-1-carboxylate (77290-31-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield: 88.0%

chloroacetonitrile (107-14-2) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(cyanomethyl)piperazine-1-carboxylate (77290-31-4)

Guidance literature:

With potassium carbonate; In acetonitrile; at 60 ℃; for 5h;

DOI:10.1007/s00706-016-1723-9

Reference yield:

ammonium chloride + chloroacetonitrile (107-14-2) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(cyanomethyl)piperazine-1-carboxylate (77290-31-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

upstream raw materials:

chloroacetonitrile

1-t-Butoxycarbonylpiperazine

cyanomethyl bromide

di-tert-butyl dicarbonate

Downstream raw materials:

C₁₉H₂₄BrN₃O₂S

(Z)-tert-butyl 4-(2-amino-2-(hydroxyimino)ethyl)piperazine-1-carboxylate

tert-butyl 4-[(5-{7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindol-5-yl}-1,2,4-oxadiazol-3-yl)methyl]piperazine-1-carboxylate

7-methyl-5-[(3-piperazin-1-ylmethyl)-1,2,4-oxadiazol-5-yl]-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one methanesulphonate